Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

Jean Pierre Vartanian (1) , Michel Henry (1) , Simon Wain-Hobson (1)

1 Rétrovirologie Moléculaire

Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G→A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.

Domaines: Sciences du Vivant [q-bio]

Jean Pierre Vartanian, Michel Henry, Simon Wain-Hobson. Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome. Journal of General Virology, 2002, 83 (4), pp.801-805. ⟨10.1099/0022-1317-83-4-801⟩. ⟨pasteur-03520178⟩