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Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

Abstract : Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G→A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03520178
Contributor : Jean-Pierre Vartanian Connect in order to contact the contributor
Submitted on : Monday, January 10, 2022 - 7:53:48 PM
Last modification on : Thursday, January 13, 2022 - 5:59:01 PM

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Jean Pierre Vartanian, Michel Henry, Simon Wain-Hobson. Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome. Journal of General Virology, Microbiology Society, 2002, 83 (4), pp.801-805. ⟨10.1099/0022-1317-83-4-801⟩. ⟨pasteur-03520178⟩

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