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Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools

Abstract : Human immunodeficiency virus type 1 (HIV-1) replication is shown to be sensitive to the intracellular concentration of deoxynucleoside triphosphate substrates. Addition of thymidine to established cell lines resulted in a dramatic reduction of virus production. The effect could be substantially alleviated by addition of deoxycytidine, which, alone, enhanced viral titers by a factor of 2 to 3. Hydroxyurea treatment abolished HIV-1 replication in peripheral blood mononuclear cells and could be reversed by deoxyadenosine. These data show that HIV-1 replication occurs under suboptimal DNA precursor conditions.
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Contributor : Jean-Pierre Vartanian Connect in order to contact the contributor
Submitted on : Monday, January 10, 2022 - 7:32:46 PM
Last modification on : Friday, January 14, 2022 - 6:22:24 PM

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A Meyerhans, Jean Pierre Vartanian, C Hultgren, U Plikat, A Karlsson, et al.. Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools. Journal of Virology, American Society for Microbiology, 1994, 68 (1), pp.535-540. ⟨10.1128/JVI.68.1.535-540.1994⟩. ⟨pasteur-03520163⟩

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