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In vivo persistence of a HIV-1-encoded HLA-B27-restricted cytotoxic T lymphocyte epitope despite specificin vitro reactivity

Abstract : A large number of human immunodeficiency virus type 1 (HIV-1) specific HLA-restricted cytotoxic T cell (CTL) epitopes have been mapped, including an HLA-B27-restricted immunodominant epitope within p25gag. Accordingly, this segment of the HIV-1 provirus was amplified by the polymerase chain reaction from DNA derived from fresh uncultured peripheral blood mononuclear cells (PBMC) of four HLA-B27 HIV-1-infected individuals. In all cases the majority of infected PBMC bore sequences encoding the HLA-B27-restricted peptide. CTL escape mutants had not accumulated in vivo 8 and 14 months later despite demonstrable CTL activity in vitro. These data emphasize the importance of silently infected lymphocytes in evading immune surveillance.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03520130
Contributor : Jean-Pierre Vartanian Connect in order to contact the contributor
Submitted on : Monday, January 10, 2022 - 7:11:35 PM
Last modification on : Thursday, April 7, 2022 - 10:10:55 AM

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Andreas Meyerhans, Gilles Dadaglio, Jean Pierre Vartanian, Pierre Langlade-Demoyen, Ronald Frank, et al.. In vivo persistence of a HIV-1-encoded HLA-B27-restricted cytotoxic T lymphocyte epitope despite specificin vitro reactivity. European Journal of Immunology, 1991, 21 (10), pp.2637-2640. ⟨10.1002/eji.1830211051⟩. ⟨pasteur-03520130⟩

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