Orthologous Mammalian APOBEC3A Cytidine Deaminases Hypermutate Nuclear DNA - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Molecular Biology and Evolution Année : 2014

Orthologous Mammalian APOBEC3A Cytidine Deaminases Hypermutate Nuclear DNA

Résumé

The human APOBEC3 gene cluster locus encodes polynucleotide cytidine deaminases. Although many act as viral restriction factors through mutation of single-stranded DNA, recent reports have shown that human APOBEC3A was capable of efficiently hypermutating nuclear DNA and inducing DNA breaks in genomic DNA. In addition, the enzyme was unique in efficiently deaminating 5-methylcytidine in single-stranded DNA. To appreciate the evolutionary relevance of these activities, we analyzed A3A-related enzymes from the rhesus and tamarin monkey, horse, sheep, dog, and panda. All proved to be orthologous to the human enzyme in all these activities revealing strong conservation more than 148 My. Hence, their singular role in DNA catabolism is a well-established mechanism probably outweighing any deleterious or pathological roles such as genomic instability and cancer formation.
Fichier principal
Vignette du fichier
mst195.pdf (1.33 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

pasteur-03520074 , version 1 (10-01-2022)

Identifiants

Citer

Vincent Caval, Rodolphe Suspène, Jean Pierre Vartanian, Simon Wain-Hobson. Orthologous Mammalian APOBEC3A Cytidine Deaminases Hypermutate Nuclear DNA. Molecular Biology and Evolution, 2014, 31 (2), pp.330-340. ⟨10.1093/molbev/mst195⟩. ⟨pasteur-03520074⟩

Collections

PASTEUR
19 Consultations
33 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More