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Decoding the dynamics of T cell-dendritic cell interactions in vivo

Abstract : T lymphocytes receive activation signals during their encounters with antigen-bearing dendritic cells (DCs) in secondary lymphoid organs. With the recent application of two-photon imaging to visualize immune responses as they happen, the dynamics of T cell-DC interactions have been dissected in several mouse models. As we are integrating the results of these new studies, we are learning that the dynamics of T cell-DC interactions are regulated by multiple immunological parameters and, most importantly, that the spatiotemporal characteristics of these cell-cell contacts encode part of the T-cell fate.
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Submitted on : Friday, January 7, 2022 - 4:35:11 PM
Last modification on : Thursday, April 7, 2022 - 10:10:29 AM

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Susanna Celli, Zacarias Garcia, Hélène Beuneu, Philippe Bousso. Decoding the dynamics of T cell-dendritic cell interactions in vivo. Immunological Reviews, Wiley, 2008, 221 (1), pp.182-187. ⟨10.1111/j.1600-065X.2008.00588.x⟩. ⟨pasteur-03517245⟩

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