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Journal articles
CD4 T cells integrate signals delivered during successive DC encounters in vivo
Abstract : The cellular mode of T cell priming in vivo remains to be characterized fully. We investigated the fate of T cell-dendritic cell (DC) interactions in the late phase of T cell activation in the lymph node. In general, CD4 T cells detach from DCs before undergoing cell division. Using a new approach to track the history of antigen (Ag)-recognition events, we demonstrated that activated/divided T cells reengage different DCs in an Ag-specific manner. Two-photon imaging of intact lymph nodes suggested that T cells could establish prolonged interactions with DCs at multiple stages during the activation process. Importantly, signals that are delivered during subsequent DC contacts are integrated by the T cell and promote sustained IL-2R ␣ expression and IFN-␥ production. Thus, repeated encounters with Ag-bearing DCs can occur in vivo and modulate CD4 T cell differentiation programs.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03513333
Contributor : Susanna Celli Connect in order to contact the contributor
Submitted on : Wednesday, January 5, 2022 - 6:23:24 PM
Last modification on : Thursday, January 13, 2022 - 2:17:09 PM
Contributor : Susanna Celli Connect in order to contact the contributor
Submitted on : Wednesday, January 5, 2022 - 6:23:24 PM
Last modification on : Thursday, January 13, 2022 - 2:17:09 PM
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SCelli_JExMed_05.pdf
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