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CD4 T cells integrate signals delivered during successive DC encounters in vivo

Susanna Celli 1 Zacarias Garcia 1 Philippe Bousso 1, * 
* Corresponding author
Abstract : The cellular mode of T cell priming in vivo remains to be characterized fully. We investigated the fate of T cell-dendritic cell (DC) interactions in the late phase of T cell activation in the lymph node. In general, CD4 T cells detach from DCs before undergoing cell division. Using a new approach to track the history of antigen (Ag)-recognition events, we demonstrated that activated/divided T cells reengage different DCs in an Ag-specific manner. Two-photon imaging of intact lymph nodes suggested that T cells could establish prolonged interactions with DCs at multiple stages during the activation process. Importantly, signals that are delivered during subsequent DC contacts are integrated by the T cell and promote sustained IL-2R ␣ expression and IFN-␥ production. Thus, repeated encounters with Ag-bearing DCs can occur in vivo and modulate CD4 T cell differentiation programs.
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Susanna Celli, Zacarias Garcia, Philippe Bousso. CD4 T cells integrate signals delivered during successive DC encounters in vivo. Journal of Experimental Medicine, 2005, 202 (9), pp.1271 - 1278. ⟨10.1084/jem.20051018⟩. ⟨pasteur-03513333⟩

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