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Fungal cell wall components modulate our immune system

Abstract : Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of fungal interactions with the immune system. Here, we highlight new advancements pointing out the pivotal role of fungal cell wall components (β-glucan, mannan, galactosaminogalactan and melanin) in modulating host immunity and discuss how these open new opportunities for the development of immunomodulatory strategies to combat deadly fungal infectious diseases.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03501321
Contributor : Thierry Fontaine Connect in order to contact the contributor
Submitted on : Thursday, December 23, 2021 - 10:03:32 AM
Last modification on : Monday, November 14, 2022 - 1:46:12 AM

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Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

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Benoit Briard, Thierry Fontaine, Thirumala-Devi Kanneganti, Neil A.R. Gow, Nicolas Papon. Fungal cell wall components modulate our immune system. The Cell Surface, 2021, 7, pp.100067. ⟨10.1016/j.tcsw.2021.100067⟩. ⟨pasteur-03501321⟩

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