UA - Université d'Angers : SFR 4208 (Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01 - France)
Abstract : Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of fungal interactions with the immune system. Here, we highlight new advancements pointing out the pivotal role of fungal cell wall components (β-glucan, mannan, galactosaminogalactan and melanin) in modulating host immunity and discuss how these open new opportunities for the development of immunomodulatory strategies to combat deadly fungal infectious diseases.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03501321 Contributor : Thierry FontaineConnect in order to contact the contributor Submitted on : Thursday, December 23, 2021 - 10:03:32 AM Last modification on : Tuesday, May 17, 2022 - 10:58:37 AM