Necker-Pasteur Clinical Metagenomics: Part 2. Contribution to Pathogen Discovery

Philippe Pérot (1) , Béatrice Regnault (1) , Franck Bielle (2) , Jacques Fourgeaud (3) , Éric Troadec (1) , Nicolas da Rocha (1) , Delphine Chrétien (1) , Thomas Bigot (1) , Marianne Leruez-Ville (3) , Agnès Ferroni (3) , Danielle Seilhean (2) , Anne Jamet (3) , Marc Eloit (1)

1 Découverte de pathogènes – Pathogen discovery
2 CHU Pitié-Salpêtrière [AP-HP]
3 Laboratoire de Microbiologie Clinique [AP-HP Hôpital Necker-Enfants Malades]

Clinical metagenomics fuels pathogen discovery but a comprehensive research environment is required to address critical questions such as imputability, physiopathology of novel identified infectious agents, and development of new diagnostic tools. The Institut Pasteur, in close collaboration with specialized hospital clinical services and laboratories including (neuro)pathologists, along with other academic labs, seeks to address these topics. We review some of the major identifications done in the course of our historical partnership with hospitals, by highlighting the place and the contribution of research works following identification of new or unexpected microorganisms. The list includes novel human pathogens with a zoonotic potential (Astrovirus VA1, Umbre orthobunyavirus, European Bat Lyssavirus 1) and known pathogens with unexpected or atypical presentation (Rubella virus, Rabies, Dengue).

Mots clés: virology; metagenomics; clinical metagenomics; pathology; encephalitis; granulomas; astrovirus; rubella virus; dengue; lyssavirus; rabies; umbre virus

Domaines: Virologie; Génomique, Transcriptomique et Protéomique [q-bio.GN]; Anatomie, Histologie, Anatomopathologie [q-bio.TO]

Philippe Pérot, Béatrice Regnault, Franck Bielle, Jacques Fourgeaud, Éric Troadec, et al.. Necker-Pasteur Clinical Metagenomics: Part 2. Contribution to Pathogen Discovery. 6th International Conference on Clinical Metagenomics, Oct 2021, Geneva, Switzerland. . ⟨pasteur-03467165⟩