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BiteOscope, an open platform to study mosquito biting behavior

Abstract : Female mosquitoes need a blood meal to reproduce, and in obtaining this essential nutrient they transmit deadly pathogens. Although crucial for the spread of mosquito-borne diseases, blood feeding remains poorly understood due to technological limitations. Indeed, studies often expose human subjects to assess biting behavior. Here, we present the biteOscope, a device that attracts mosquitoes to a host mimic which they bite to obtain an artificial blood meal. The host mimic is transparent, allowing high-resolution imaging of the feeding mosquito. Using machine learning, we extract detailed behavioral statistics describing the locomotion, pose, biting, and feeding dynamics of Aedes aegypti, Aedes albopictus, Anopheles stephensi, and Anopheles coluzzii. In addition to characterizing behavioral patterns, we discover that the common insect repellent DEET repels Anopheles coluzzii upon contact with their legs. The biteOscope provides a new perspective on mosquito blood feeding, enabling the high-throughput quantitative characterization of this lethal behavior.
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Contributor : Felix Hol Connect in order to contact the contributor
Submitted on : Thursday, November 25, 2021 - 11:09:18 AM
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Hol eLife 2020.pdf
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Felix Jh Hol, Louis Lambrechts, Manu Prakash. BiteOscope, an open platform to study mosquito biting behavior. eLife, eLife Sciences Publication, 2020, 9, pp.e56829. ⟨10.7554/elife.56829⟩. ⟨pasteur-03448539⟩



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