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GATA-3 promotes T-cell specification by repressing B-cell potential in pro–T cells in mice

Abstract : Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint involves Notch1 signaling that instructs T-cell commitment at the expense of the B-lineage program. While GATA-3 is required for T-cell specification, its mechanism of action is poorly understood. We show that GATA-3 works in concert with Notch1 to commit thymic progenitors to the T-cell lineage via 2 distinct pathways. First, GATA-3 orchestrates a transcriptional “repertoire” that is required for thymocyte maturation up to and beyond the pro–T-cell stage. Second, GATA-3 critically suppresses a latent B-cell potential in pro–T cells. As such, GATA-3 is essential to sealing in Notch-induced T-cell fate in early thymocyte precursors by promoting T-cell identity through the repression of alternative developmental options.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03431420
Contributor : Odile Richard-Le Goff Connect in order to contact the contributor
Submitted on : Tuesday, November 16, 2021 - 4:32:01 PM
Last modification on : Friday, November 19, 2021 - 3:10:36 AM

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Marcos García-Ojeda, Roel Klein Wolterink, Fabrice Lemaître, Odile Richard Le Goff, Milena Hasan, et al.. GATA-3 promotes T-cell specification by repressing B-cell potential in pro–T cells in mice. Blood, American Society of Hematology, 2013, 121 (10), pp.1749-1759. ⟨10.1182/blood-2012-06-440065⟩. ⟨pasteur-03431420⟩

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