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Journal Articles Nature Reviews Chemistry Year : 2021

Towards the sustainable discovery and development of new antibiotics

1 HZI - Helmholtz-Zentrum für Infektionsforschung GmbH
2 Universität des Saarlandes [Saarbrücken]
3 DZIF - German Centre for Infection Research
4 UNIPR - Università degli studi di Parma = University of Parma
5 DTU - Danmarks Tekniske Universitet = Technical University of Denmark
6 JLU - Justus-Liebig-Universität Gießen = Justus Liebig University
7 EpiCBio - Chimie biologique épigénétique - Epigenetic Chemical Biology
8 EERA - Écologie et Évolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance
9 DynAMic - Dynamique des Génomes et Adaptation Microbienne
10 Goethe-Universität Frankfurt am Main
11 Max Planck Institute for Terrestrial Microbiology
12 ULISBOA - Universidade de Lisboa = University of Lisbon
13 MCAM - Molécules de Communication et Adaptation des Micro-organismes
14 WUR - Wageningen University and Research [Wageningen]
15 I2BC - Institut de Biologie Intégrative de la Cellule
16 Fundación MEDINA [Granada]
17 John Innes Centre [Norwich]
18 IMoPA - Ingénierie Moléculaire et Physiopathologie Articulaire
19 University of Manchester [Manchester]
20 UNIPG - Università degli Studi di Perugia = University of Perugia
21 University of Tübingen
22 Institut de Chimie de Strasbourg
23 Jacobs University [Bremen]
24 University Hospital Bonn
25 Biophys [Usk, UK]
26 University of Bristol [Bristol]
27 Recursion [Salt Lake City, UT]
28 HiberCell [New York]
29 Uppsala Universitet [Uppsala]
30 AMR Insights
31 University of Ljubljana
32 BEAM Alliance
33 Naicons
34 Drugs for Neglected Diseases Initiative
35 GARDP - Global Antibiotic Research and Development Partnership [Geneva, Switzerland]
36 University of Dundee
37 NIBR - Novartis Institutes for BioMedical Research
Andrew W. Truman
Eriko Takano
Myriam Seemann
Mathias Winterhalter
Heather Graz
  • Function : Author
Michael Graz
Maarten van Dongen
  • Function : Author
Frédéric Peyrane
  • Function : Author
Stefano Donadio
  • Function : Author
Ian H. Gilbert
Heinz E. Moser

Abstract

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
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Dates and versions

pasteur-03427787 , version 1 (23-11-2021)

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Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, et al.. Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩. ⟨pasteur-03427787⟩
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