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Towards the sustainable discovery and development of new antibiotics

Marcus Miethke 1, 2, 3 Marco Pieroni 4 Tilmann Weber 5 Mark Brönstrup 3, 1 Peter Hammann 6 Ludovic Halby 7 Paola B. Arimondo 7 Philippe Glaser 8 Bertrand Aigle 9 Helge Bode 10, 11 Rui Moreira 12 Yanyan Li 13 Andriy Luzhetskyy 2 Marnix Medema 14 Jean-Luc Pernodet 15 Marc Stadler 3, 1 José Rubén Tormo 16 Olga Genilloud 16 Andrew Truman 17 Kira Weissman 18 Eriko Takano 19 Stefano Sabatini 20 Evi Stegmann 3, 21 Heike Brötz-Oesterhelt 3, 21 Wolfgang Wohlleben 3, 21 Myriam Seemann 22 Martin Empting 1, 2, 3 Anna Hirsch 1, 2, 3 Brigitta Loretz 1, 2 Claus-Michael Lehr 1, 2 Alexander Titz 1, 2, 3 Jennifer Herrmann 1, 2, 3 Timo Jaeger 3 Silke Alt 3 Thomas Hesterkamp 3 Mathias Winterhalter 23 Andrea Schiefer 3, 24 Kenneth Pfarr 3, 24 Achim Hoerauf 3, 24 Heather Graz 25 Michael Graz 26 Mika Lindvall 27 Savithri Ramurthy 28 Anders Karlén 29 Maarten van Dongen 30 Hrvoje Petkovic 31 Andreas Keller 2 Frédéric Peyrane 32 Stefano Donadio 33 Laurent Fraisse 34 Laura Piddock 35 Ian Gilbert 36 Heinz Moser 37, * Rolf Müller 1, 2, 3, *
* Corresponding author
Abstract : An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03427787
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Submitted on : Tuesday, November 23, 2021 - 4:52:30 PM
Last modification on : Wednesday, December 1, 2021 - 4:40:01 PM

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Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, et al.. Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry, Nature Publishing Group, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩. ⟨pasteur-03427787⟩

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