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Journal Articles Nature Reviews Chemistry Year : 2021

Towards the sustainable discovery and development of new antibiotics

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Andrew W. Truman
Eriko Takano
Myriam Seemann
Mathias Winterhalter
Heather Graz
  • Function : Author
Michael Graz
Maarten van Dongen
  • Function : Author
Frédéric Peyrane
  • Function : Author
Stefano Donadio
  • Function : Author
Ian H. Gilbert
Heinz E. Moser

Abstract

An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
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Dates and versions

pasteur-03427787 , version 1 (23-11-2021)

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Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, et al.. Towards the sustainable discovery and development of new antibiotics. Nature Reviews Chemistry, 2021, 5 (10), pp.726-749. ⟨10.1038/s41570-021-00313-1⟩. ⟨pasteur-03427787⟩
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