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Journal articles
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters
Phanramphoei Frantz
1, 2, 3
Aleksandr Barinov
1, 2, 4
Claude Ruffié
1, 2
Chantal Combredet
1, 2
Valérie Najburg
1, 2
Guilherme Dias de Melo
5
Florence Larrous
5
Lauriane Kergoat
5
Samaporn Teeravechyan
3
Anan Jongkaewwattana
3
Emmanuelle Billon-Denis
6
Jean-Nicolas Tournier
6
Matthieu Prot
7
Laurine Levillayer
7
Laurine Conquet
8
Xavier Montagutelli
8
Magali Tichit
9
David Hardy
9
Priyanka Fernandes
10
Hélène Strick-Marchand
10
James Di Santo
10
Etienne Simon-Lorière
7
Hervé Bourhy
5
Frédéric Tangy
1, 2, *
*
Corresponding author
Phanramphoei N. Frantz 1, 2, 3
Author
Aleksandr Barinov 1, 2, 4
Author ORCID : https://orcid.org/0000-0003-2530-5081
Claude Ruffié 1, 2
Author
Chantal Combredet 1, 2
Author IdHAL : chantal-combredet ORCID : https://orcid.org/0000-0002-2161-199X
Valérie Najburg 1, 2
Author
Guilherme Dias de Melo 5
Author IdHAL : guilherme-dias-de-melo ResearcherId : http://www.researcherid.com/rid/E-1691-2012
Florence Larrous 5
Author ORCID : https://orcid.org/0000-0003-0881-4263
Lauriane Kergoat 5
Author ORCID : https://orcid.org/0000-0002-5609-4398
Samaporn Teeravechyan 3
Author
Anan Jongkaewwattana 3
Author
Emmanuelle Billon-Denis 6
Author
Jean-Nicolas Tournier 6
Author ORCID : https://orcid.org/0000-0002-4542-2421
Matthieu Prot 7
Author
Laurine Levillayer 7
Author
Laurine Conquet 8
Author
Xavier Montagutelli 8
Author IdHAL : xavier-montagutelli ORCID : https://orcid.org/0000-0002-9372-5398
Magali Tichit 9
Author
David Hardy 9
Author IdHAL : david-hardy ORCID : https://orcid.org/0000-0001-5874-4377
Priyanka Fernandes 10
Author
Hélène Strick-Marchand 10
Author
James Di Santo 10
Author ORCID : https://orcid.org/0000-0002-7146-1862
Etienne Simon-Lorière 7
Author IdHAL : etiennesimon-loriere ORCID : https://orcid.org/0000-0001-8420-7743
Hervé Bourhy 5
Author IdHAL : herve-bourhy ORCID : https://orcid.org/0000-0002-2608-5589
Frédéric Tangy 1, 2
Correspondent author ORCID : https://orcid.org/0000-0002-5937-5654
1
Laboratoire d’innovation : vaccins – Innovation lab : vaccines (Département de virologie
25-28 rue du Docteur Roux
75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
2
UP - Université de Paris (85 boulevard Saint-Germain
75006 Paris - France)
4
VIROxIS [Villejuif] (France)
- IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
5
Lyssavirus, épidémiologie et neuropathologie - Lyssavirus Epidemiology and Neuropathology (Département de santé globale - 25-28 rue du Docteur Roux 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
6
IRBA - Institut de Recherche Biomédicale des Armées (Brétigny-sur-Orge - France)
7
Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses (Département de Virologie
25-28 rue du Docteur Roux
75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
8
Génétique de la souris - Mouse Genetics (Département Génomes et Génétique -
25-28 rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
9
Neuropathologie expérimentale / Experimental neuropathology (Department of Global Health
28 rue du Docteur Roux
75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- UP - Université de Paris (85 boulevard Saint-Germain 75006 Paris - France)
10
Immunité Innée - Innate Immunity (Département d'Immunologie, 25-28 rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1223 (101, rue de Tolbiac, 75013 Paris - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
Abstract : Several COVID-19 vaccines have now been deployed to tackle the SARS-CoV-2 pandemic, most of them based on messenger RNA or adenovirus vectors.The duration of protection afforded by these vaccines is unknown, as well as their capacity to protect from emerging new variants. To provide sufficient coverage for the world population, additional strategies need to be tested. The live pediatric measles vaccine (MV) is an attractive approach, given its extensive safety and efficacy history, along with its established large-scale manufacturing capacity. We develop an MV-based SARS-CoV-2 vaccine expressing the prefusion-stabilized, membrane-anchored full-length S antigen, which proves to be efficient at eliciting strong Th1-dominant T-cell responses and high neutralizing antibody titers. In both mouse and golden Syrian hamster models, these responses protect the animals from intranasal infectious challenge. Additionally, the elicited antibodies efficiently neutralize in vitro the three currently circulating variants of SARS-CoV-2.
Document type :
Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03416317
Contributor : David Hardy Connect in order to contact the contributor
Submitted on : Friday, November 5, 2021 - 11:04:18 AM
Last modification on : Monday, November 29, 2021 - 2:38:01 PM
Contributor : David Hardy Connect in order to contact the contributor
Submitted on : Friday, November 5, 2021 - 11:04:18 AM
Last modification on : Monday, November 29, 2021 - 2:38:01 PM
File
s41467-021-26506-2.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : pasteur-03416317, version 1
- DOI : 10.1038/s41467-021-26506-2
- PUBMED : 34725327
Citation
Phanramphoei Frantz, Aleksandr Barinov, Claude Ruffié, Chantal Combredet, Valérie Najburg, et al.. A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.6277. ⟨10.1038/s41467-021-26506-2⟩. ⟨pasteur-03416317⟩
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