A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2021

A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters

(1, 2, 3) , (1, 2, 4, 5) , (1, 2) , (1, 2) , (1, 2) , (6) , (6) , (6) , (3) , (3) , (7) , (7) , (8) , (8) , (9) , (9) , (10) , (10) , (11) , (11) , (11) , (8) , (6) , (1, 2)
1
2
3
4
5
6
7
8
9
10
11
James Di Santo

Abstract

Several COVID-19 vaccines have now been deployed to tackle the SARS-CoV-2 pandemic, most of them based on messenger RNA or adenovirus vectors.The duration of protection afforded by these vaccines is unknown, as well as their capacity to protect from emerging new variants. To provide sufficient coverage for the world population, additional strategies need to be tested. The live pediatric measles vaccine (MV) is an attractive approach, given its extensive safety and efficacy history, along with its established large-scale manufacturing capacity. We develop an MV-based SARS-CoV-2 vaccine expressing the prefusion-stabilized, membrane-anchored full-length S antigen, which proves to be efficient at eliciting strong Th1-dominant T-cell responses and high neutralizing antibody titers. In both mouse and golden Syrian hamster models, these responses protect the animals from intranasal infectious challenge. Additionally, the elicited antibodies efficiently neutralize in vitro the three currently circulating variants of SARS-CoV-2.
Fichier principal
Vignette du fichier
s41467-021-26506-2.pdf (2.19 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03416317 , version 1 (05-11-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Phanramphoei N. Frantz, Aleksandr Barinov, Claude Ruffié, Chantal Combredet, Valérie Najburg, et al.. A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters. Nature Communications, 2021, 12 (1), pp.6277. ⟨10.1038/s41467-021-26506-2⟩. ⟨pasteur-03416317⟩
288 View
36 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More