ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains

Jan Madacki (1) , Mickael Orgeur (1) , Guillem Mas Fiol (1) , Wafa Frigui (1) , Laurence Ma (2) , Roland Brosch (1)

1 Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics
2 C2RT - Pôle Biomics

Data on the bacterial sex-mediated impact on mycobacterial evolution are limited. Hence, our results presented here are of importance as they clearly demonstrate the capacity of a wide range of human- and animal-adapted Mycobacterium tuberculosis complex (MTBC) strains to transfer chromosomal DNA to selected strains of Mycobacterium canettii .

Keywords: DNA transfer; ESX-1; Mycobacterium canettii; Mycobacterium tuberculosis; conjugation; recombinant

Domains: Life Sciences [q-bio]; Biochemistry, Molecular Biology; Biochemistry [q-bio.BM]; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]

Jan Madacki, Mickael Orgeur, Guillem Mas Fiol, Wafa Frigui, Laurence Ma, et al.. ESX-1-Independent Horizontal Gene Transfer by Mycobacterium tuberculosis Complex Strains. mBio, 2021, 12 (3), ⟨10.1128/mBio.00965-21⟩. ⟨pasteur-03413286⟩