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Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus

Abstract : Influenza virus RNA-dependent RNA polymerase (FluPol) transcribes the viral RNA genome in the infected cell nucleus. In the 1970s, researchers showed that viral transcription depends on host RNA polymerase II (RNAP II) activity and subsequently that FluPol snatches capped oligomers from nascent RNAP II transcripts to prime its own transcription. Exactly how this occurs remains elusive. Here, we review recent advances in the mechanistic understanding of FluPol transcription and early events in RNAP II transcription that are relevant to cap-snatching. We describe the known direct interactions between FluPol and the RNAP II C-terminal domain and summarize the transcription-related host factors that have been found to interact with FluPol. We also discuss open questions regarding how FluPol may be targeted to actively transcribing RNAP II and the exact context and timing of cap-snatching, which is presumed to occur after cap completion but before the cap is sequestered by the nuclear cap-binding complex.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03408583
Contributor : Nadia Naffakh Connect in order to contact the contributor
Submitted on : Tuesday, November 9, 2021 - 12:08:39 PM
Last modification on : Wednesday, December 1, 2021 - 2:34:03 PM

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Tim Krischuns, Maria Lukarska, Nadia Naffakh, Stephen Cusack. Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus. Annual Review of Biochemistry, Annual Reviews, 2021, 90 (1), pp.321-348. ⟨10.1146/annurev-biochem-072820-100645⟩. ⟨pasteur-03408583⟩

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