Prevalence and Factors Associated with Maternal Group B Streptococcus Colonization in Madagascar and Senegal

Yu-Jin Jung (1) , Bich-Tram Huynh (2) , Abdoulaye Seck (1, 3) , Raymond Bercion (1) , Fatoumata Diene Sarr (1) , Perlinot Herindrainy (4) , Jean-Baptiste Diouf , Zafitsara Zo Andrianirina (5) , Arnaud Firon (6) , Patrick Trieu-Cuot (6) , Sophie Goyet (7) , Jean-Marc Collard (7) , Elisabeth Delaroque-Astagneau (8, 9) , Didier Guillemot (2, 9) , Muriel Vray (1, 10, 11) , Birdy Study Group

1 Institut Pasteur de Dakar
2 Pharmacoépidémiologie et maladies infectieuses
3 UCAD - Université Cheikh Anta Diop [Dakar, Sénégal]
4 Institut Pasteur de Madagascar
5 CENHOSOA - Centre Hospitalier de Soavinandriana
6 Biologie des Bactéries pathogènes à Gram-positif - Biology of Gram-Positive Pathogens
7 Institut Pasteur du Cambodge
8 Université Paris Saclay (COmUE)
9 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
10 INSERM - Institut National de la Santé et de la Recherche Médicale
11 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology

Maternal group B Streptococcus (GBS) colonization is a major risk factor for neonatal GBS infection. However, data on GBS are scarce in low- and middle-income countries. Using sociodemographic data and vaginal swabs collected from an international cohort of mothers and newborns, this study aimed to estimate the prevalence of GBS colonization among pregnant women in Madagascar ( n = 1,603) and Senegal ( n = 616). The prevalence was 5.0% (95% CI, 3.9–6.1) and 16.1% (95% CI, 13.1–19.0) in Madagascar and Senegal, respectively. No factors among sociodemographic characteristics, living conditions, and obstetric history were found to be associated independently with GBS colonization in both countries. This community-based study provides one of the first estimates of maternal GBS colonization among pregnant women from Madagascar and Senegal.

Domains: Life Sciences [q-bio]

Yu-Jin Jung, Bich-Tram Huynh, Abdoulaye Seck, Raymond Bercion, Fatoumata Diene Sarr, et al.. Prevalence and Factors Associated with Maternal Group B Streptococcus Colonization in Madagascar and Senegal. American Journal of Tropical Medicine and Hygiene, 2021, ⟨10.4269/ajtmh.21-0113⟩. ⟨pasteur-03356643⟩