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Evolution of Bordetella pertussis over a 23-year period in France, 1996 to 2018

Abstract : Background: Bordetella pertussis is the main agent of whooping cough. Vaccination with acellular pertussis vaccines has been largely implemented in high-income countries. These vaccines contain 1 to 5 antigens: pertussis toxin (PT), filamentous haemagglutinin (FHA), pertactin (PRN) and/or fimbrial proteins (FIM2 and FIM3). Monitoring the emergence of B. pertussis isolates that might partially escape vaccine-induced immunity is an essential component of public health strategies to control whooping cough. Aim: We aimed to investigate temporal trends of fimbriae serotypes and vaccine antigenexpression in B. pertussis over a 23-year period in France (1996-2018). Methods: Isolates (n = 2,280) were collected through hospital surveillance, capturing one third of hospitalised paediatric pertussis cases. We assayed PT, FHA and PRN production by Western blot (n = 1,428) and fimbriae production by serotyping (n = 1,058). Molecular events underlying antigen deficiency were investigated by genomic sequencing.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03349287
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Submitted on : Monday, September 20, 2021 - 2:07:55 PM
Last modification on : Tuesday, October 19, 2021 - 10:29:33 PM

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Valérie Bouchez, Sophie Guillot, Annie Landier, Nathalie Armatys, Soraya Matczak, et al.. Evolution of Bordetella pertussis over a 23-year period in France, 1996 to 2018. Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (37), ⟨10.2807/1560-7917.ES.2021.26.37.2001213⟩. ⟨pasteur-03349287⟩

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