Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue PLoS Neglected Tropical Diseases Année : 2021

Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities

Wang Nguitragool

Résumé

Background Understanding epidemiological variables affecting gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission. Methodology/Principal findings Plasmodium falciparum and P . vivax parasites and gametocytes were quantified by qPCR and RT-qPCR assays using the same methodologies in 5 cross-sectional surveys involving 16,493 individuals in Brazil, Thailand, Papua New Guinea, and Solomon Islands. The proportion of infections with detectable gametocytes per survey ranged from 44–94% for P . falciparum and from 23–72% for P . vivax . Blood-stage parasite density was the most important predictor of the probability to detect gametocytes. In moderate transmission settings (prevalence by qPCR>5%), parasite density decreased with age and the majority of gametocyte carriers were children. In low transmission settings (prevalence<5%), >65% of gametocyte carriers were adults. Per survey, 37–100% of all individuals positive for gametocytes by RT-qPCR were positive by light microscopy for asexual stages or gametocytes (overall: P . falciparum 178/348, P . vivax 235/398). Conclusions/Significance Interventions to reduce human-to-mosquito malaria transmission in moderate-high endemicity settings will have the greatest impact when children are targeted. In contrast, all age groups need to be included in control activities in low endemicity settings to achieve elimination. Detection of infections by light microscopy is a valuable tool to identify asymptomatic blood stage infections that likely contribute most to ongoing transmission at the time of sampling.
Fichier principal
Vignette du fichier
journal.pntd.0009672.pdf (1.55 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

pasteur-03344146 , version 1 (14-09-2021)

Licence

Paternité

Identifiants

Citer

Cristian Koepfli, Wang Nguitragool, Anne Cristine Gomes de Almeida, Andrea Kuehn, Andreea Waltmann, et al.. Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities. PLoS Neglected Tropical Diseases, 2021, 15 (8), pp.e0009672. ⟨10.1371/journal.pntd.0009672⟩. ⟨pasteur-03344146⟩
45 Consultations
37 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More