Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection - Institut Pasteur Accéder directement au contenu
Article Dans Une Revue Science Advances Année : 2021

Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection

Timothée Bruel
Aurélien Corneau
Isabelle Staropoli
Olivier Peyrony
Catherine Blanc

Résumé

The COVID-19 pandemic has spread worldwide, yet the role of antiviral T cell immunity during infection and the contribution of immune checkpoints remain unclear. By prospectively following a cohort of 292 patients with melanoma, half of which treated with immune checkpoint inhibitors (ICIs), we identified 15 patients with acute or convalescent COVID-19 and investigated their transcriptomic, proteomic, and cellular profiles. We found that ICI treatment was not associated with severe COVID-19 and did not alter the induction of inflammatory and type I interferon responses. In-depth phenotyping demonstrated expansion of CD8 effector memory T cells, enhanced T cell activation, and impaired plasmablast induction in ICI-treated COVID-19 patients. The evaluation of specific adaptive immunity in convalescent patients showed higher spike (S), nucleoprotein (N), and membrane (M) antigen-specific T cell responses and similar induction of spike-specific antibody responses. Our findings provide evidence that ICI during COVID-19 enhanced T cell immunity without exacerbating inflammation.

Domaines

Immunologie
Fichier principal
Vignette du fichier
sciadv.abg4081.pdf (536.13 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

pasteur-03334080 , version 1 (03-09-2021)

Licence

Paternité

Identifiants

Citer

Nader Yatim, Jeremy Boussier, Pauline Tetu, Nikaïa Smith, Timothée Bruel, et al.. Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection. Science Advances , 2021, 7 (34), pp.eabg4081. ⟨10.1126/sciadv.abg4081⟩. ⟨pasteur-03334080⟩
358 Consultations
269 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More