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Measurement of Dipeptidylpeptidase Activity in vitro and in vivo

Abstract : Dipeptidylpeptidases (DPPs) are serine proteases, which cleave small proteins and peptides possessing a proline or an alanine in the second position of their N-terminus. Among the members of this family, dipeptidylpeptidase 4 (DPP4) is constitutively expressed in the extracellular space. DPP4 is found at the surface of many hematopoietic and non-hematopoietic cells and is also present in many biological fluids in a bioactive soluble form. DPP4 expression is modulated by inflammation, and measurements of its activity have been used as biomarker for disease. Here, we describe a method to evaluate the enzymatic activity of DPP4 in vitro and in vivo.
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Submitted on : Wednesday, September 1, 2021 - 2:11:50 PM
Last modification on : Thursday, April 7, 2022 - 10:10:46 AM
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Rosa Barreira da Silva, Molly Ingersoll, Matthew Albert. Measurement of Dipeptidylpeptidase Activity in vitro and in vivo. Bio-protocol , Bio-protocol LCC, 2017, 7 (6), pp.e2184. ⟨10.21769/BioProtoc.2184⟩. ⟨pasteur-03331047⟩



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