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The global meningitis genome partnership

Elizabeth Rodgers 1, * Stephen Bentley 2 Ray Borrow 3, 4 Holly Bratcher 5 Sylvain Brisse 6 Angela Brueggemann 5 Dominique Caugant 7 Jamie Findlow 8 Leanne Fox 9 Linda Glennie 1 Lee Harrison 10 Odile Harrison 5 Robert Heyderman 11 Melissa Jansen van Rensburg 5 Keith Jolley 5 Brenda Kwambana-Adams 11 Shamez Ladhani 12, 13 Marc Laforce 14 Michael Levin 15 Jay Lucidarme 3, 4 Neil Macalasdair 2 Jenny Maclennan 5 Martin Maiden 5 Laura Maynard-Smith 5 Alessandro Muzzi 16 Philipp Oster 17 Charlene Rodrigues 5 Olivier Ronveaux 18 Laura Serino 16 Vinny Smith 1 Arie van der Ende 19, 20 Julio Vázquez 21 Xin Wang 9 Saber Yezli 22 James Stuart 18
Abstract : Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
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Submitted on : Monday, August 30, 2021 - 5:18:40 PM
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Elizabeth Rodgers, Stephen Bentley, Ray Borrow, Holly Bratcher, Sylvain Brisse, et al.. The global meningitis genome partnership. Journal of Infection, WB Saunders, 2020, 81 (4), pp.510-520. ⟨10.1016/j.jinf.2020.06.064⟩. ⟨pasteur-03329233⟩



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