Toxin-Induced Neurological Diseases

Pierre L. Goossens (1, 2) , Cédric Thépenier (1) , Michel R. Popoff (3)

1 Neuropathologie expérimentale - Experimental neuropathology
2 Yersinia
3 Toxines bactériennes - Bacterial Toxins

Toxins are diffusible molecules that act at a distance from their production site. Bacterial toxins may act either directly or indirectly on the CNS. Directly via neurological pathways (such as for the Clostridium tetani Tetanus neurotoxin[TeNT]) or via the bloodstream (such as Clostridium perfringens Epsilon toxin) – i.e. reaching the CNS through the brain-blood barrier (BBB). Indirectly, by modulating host systems that interact with the CNS, either via the peripheral nervous system (PNS) that relays the information from the periphery (the paradigm being botulinum neurotoxin [BoNT]), or via the blood compartment that bathes the brain (i.e. signal transmission through the highly adapted BBB interface).

Mots clés: bacterial toxins; tetanus toxin; botulinum toxin; Clostridium perfringens; epsilon toxin; emetic toxin; staphylococcal enterotoxins; Bacillus cereus; cereulide; shiga toxins; large clostridial toxins

Domaines: Sciences du Vivant [q-bio]

Pierre L. Goossens, Cédric Thépenier, Michel R. Popoff. Toxin-Induced Neurological Diseases. Infections of the Central Nervous System: Pathology and Genetics, 1, Wiley, 2020, 9781119467748. ⟨10.1002/9781119467748.ch43⟩. ⟨pasteur-03328918⟩