Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2020

Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia

(1, 2) , (2, 3) , (1) , (4, 1) , (1, 5) , (1, 6) , (7) , (1) , (1) , (2, 3) , (8) , (8) , (4, 1) , (1) , (9) , (1) , (1, 10) , (6) , (3) , (8) , (2) , (1)
1
2
3
4
5
6
7
8
9
10
Aurélie Labbe
  • Function : Author
Guillaume Huguet
Elise Douard

Abstract

16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging data from 101 CNV carriers, 755 individuals with idiopathic ASD, SZ, or ADHD and 1,072 controls. We characterize CNV FC-signatures and use them to identify dimensions contributing to complex idiopathic conditions. CNVs have large mirror effects on FC at the global and regional level. Thalamus, somatomotor, and posterior insula regions play a critical role in dysconnectivity shared across deletions, duplications, idiopathic ASD, SZ but not ADHD. Individuals with higher similarity to deletion FC-signatures exhibit worse cognitive and behavioral symptoms. Deletion similarities identified at the connectivity level could be related to the redundant associations observed genome-wide between gene expression spatial patterns and FC-signatures. Results may explain why many CNVs affect a similar range of neuropsychiatric symptoms.
Fichier principal
Vignette du fichier
s41467-020-18997-2.pdf (2.35 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03325396 , version 1 (24-08-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Clara A. Moreau, Sebastian G. W. Urchs, Kumar Kuldeep, Pierre Orban, Catherine Schramm, et al.. Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia. Nature Communications, 2020, 11 (1), pp.5272. ⟨10.1038/s41467-020-18997-2⟩. ⟨pasteur-03325396⟩
21 View
54 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More