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COVID-19 Research: Lessons from Non-Human Primate Models

Abstract : Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19). It emerged from China in December 2019 and rapidly spread across the globe, causing a pandemic with unprecedented impacts on public health and economy. Therefore, there is an urgent need for the development of curative treatments and vaccines. In humans, COVID-19 pathogenesis shows a wide range of symptoms, from asymptomatic to severe pneumonia. Identifying animal models of SARS-CoV-2 infection that reflect the clinical symptoms of COVID-19 is of critical importance. Nonhuman primates (NHPss) correspond to relevant models to assess vaccine and antiviral effectiveness. This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
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Submitted on : Wednesday, August 11, 2021 - 6:03:44 PM
Last modification on : Wednesday, November 17, 2021 - 12:31:41 PM
Long-term archiving on: : Friday, November 12, 2021 - 7:25:28 PM

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Distributed under a Creative Commons Attribution 4.0 International License

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Laure Albrecht, Elodie Bishop, Basile Jay, Blaise Lafoux, Marie Minoves, et al.. COVID-19 Research: Lessons from Non-Human Primate Models. Vaccines, MDPI, 2021, 9 (8), pp.886. ⟨10.3390/vaccines9080886⟩. ⟨pasteur-03319172⟩

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