Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
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Hugues Aschard
- Function : Author
- PersonId : 1071662
- ORCID : 0000-0002-7554-6783
- IdRef : 139628924
Jusheng Zheng
- Function : Author
- PersonId : 807951
- ORCID : 0000-0001-6560-4890
Mika Kähönen
- Function : Author
- PersonId : 762620
- ORCID : 0000-0002-4510-7341
Naveed Sattar
- Function : Author
- PersonId : 762622
- ORCID : 0000-0002-1604-2593
Elina Hyppönen
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- Function : Correspondent author
- PersonId : 1104484
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Peter Kraft
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Douglas P. Kiel
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Abstract
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC23A, and P = 1.9×10-14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.
Origin : Publication funded by an institution