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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Tuomas Kilpeläinen 1, 2 Amy Bentley 3 Raymond Noordam 4 Yun Ju Sung 5 Karen Schwander 5 Thomas Winkler 6 Hermina Jakupović 1 Daniel Chasman 7, 8 Alisa Manning 9, 8 Ioanna Ntalla 10 Hugues Aschard 8, 11 Michael Brown 12 Lisa de las Fuentes 13 Nora Franceschini Xiuqing Guo Dina Vojinovic Stella Aslibekyan Mary Feitosa Minjung Kho Solomon Musani Melissa Richard Heming Wang Zhe Wang Traci Bartz Lawrence Bielak Archie Campbell Rajkumar Dorajoo Virginia Fisher Fernando Hartwig Andrea Horimoto Changwei Li Kurt Lohman Jonathan Marten Xueling Sim Albert Smith Salman Tajuddin Maris Alver Marzyeh Amini Mathilde Boissel 14 Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Mariaelisa Graff Sarah Harris Meian He Fang-Chi Hsu Anne Jackson Jing Hua Zhao Aldi Kraja Brigitte Kühnel Federica Laguzzi Leo-Pekka Lyytikäinen Ilja Nolte Rainer Rauramaa Muhammad Riaz Antonietta Robino Rico Rueedi Heather Stringham Fumihiko Takeuchi Peter van der Most Tibor Varga Niek Verweij Erin Ware Wanqing Wen Xiaoyin Li Lisa Yanek Najaf Amin Donna Arnett Eric Boerwinkle Marco Brumat Brian Cade Mickaël Canouil Yii-Der Ida Chen Maria Pina Concas John Connell Renée de Mutsert H Janaka de Silva Paul de Vries Ayşe Demirkan Jingzhong Ding Charles Eaton Jessica Faul Yechiel Friedlander Kelley Gabriel Mohsen Ghanbari Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven Hunt M Arfan Ikram Jost Jonas Woon-Puay Koh Pirjo Komulainen Jose Krieger Stephen Kritchevsky Zoltán Kutalik Johanna Kuusisto Carl Langefeld Claudia Langenberg Lenore Launer Karin Leander Rozenn Lemaitre Cora Lewis Jingjing Liang Jianjun Liu Reedik Mägi Ani Manichaikul Thomas Meitinger Andres Metspalu Yuri Milaneschi Karen Mohlke Thomas Mosley Alison Murray Mike Nalls Ei-Ei Khaing Nang Christopher Nelson Sotoodehnia Nona Jill Norris Chiamaka Vivian Nwuba Jeff O'Connell Nicholette Palmer George Papanicolau Raha Pazoki Nancy Pedersen Annette Peters Patricia Peyser Ozren Polasek David Porteous Alaitz Poveda Olli Raitakari Stephen Rich Neil Risch Jennifer Robinson Lynda Rose Igor Rudan Pamela Schreiner Robert Scott Stephen Sidney Mario Sims Jennifer Smith Harold Snieder Tamar Sofer John Starr Barbara Sternfeld Konstantin Strauch Hua Tang Kent Taylor Michael Tsai Jaakko Tuomilehto André Uitterlinden M Yldau van der Ende Diana van Heemst Trudy Voortman Melanie Waldenberger Patrik Wennberg Gregory Wilson Yong-Bing Xiang Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan Zonderman Diane Becker Michael Boehnke Donald Bowden Ulf de Faire Ian Deary Paul Elliott Tõnu Esko Barry Freedman Philippe Froguel Paolo Gasparini Christian Gieger Norihiro Kato Markku Laakso Timo Lakka Terho Lehtimäki Patrik Magnusson Albertine Oldehinkel Brenda Penninx Nilesh Samani Xiao-Ou Shu Pim van der Harst Jana van Vliet-Ostaptchouk Peter Vollenweider Lynne Wagenknecht Ya Wang Nicholas Wareham David Weir Tangchun Wu Wei Zheng Xiaofeng Zhu Michele Evans Paul Franks Vilmundur Gudnason Caroline Hayward Bernardo Horta Tanika Kelly Yongmei Liu Kari North Alexandre Pereira Paul Ridker E Shyong Tai Rob van Dam Ervin Fox Sharon Kardia Ching-Ti Liu Dennis Mook-Kanamori Michael Province Susan Redline Cornelia van Duijn Jerome Rotter Charles Kooperberg W James Gauderman Bruce Psaty Kenneth Rice 15 Patricia Munroe 10 Myriam Fornage 12 L Adrienne Cupples Charles Rotimi 3 Alanna Morrison 12 Dabeeru Rao 5 Ruth Loos 2
Abstract : Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
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Submitted on : Monday, July 5, 2021 - 4:49:50 PM
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Tuomas Kilpeläinen, Amy Bentley, Raymond Noordam, Yun Ju Sung, Karen Schwander, et al.. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.376. ⟨10.1038/s41467-018-08008-w⟩. ⟨pasteur-03278556⟩

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