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Innate immune responses to Listeria in vivo

Claire Maudet 1 Sylvain Levallois 1, 2 Olivier Disson 1 Marc Lecuit 1, 2, 3, 4, 5, 6, 7, *
* Corresponding author
1 Biologie des Infections - Biology of Infection
2 UP - Université de Paris
3 CNRL - Centre National de Référence Listeria - Biologie des Infections
4 CCOMS - Centre collaborateur de l'OMS Listeria - Biologie des Infections
5 CHU Necker - Enfants Malades [AP-HP]
6 Service des Maladies infectieuses et tropicales [CHU Necker]
7 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)
Abstract : Listeria monocytogenes (Lm) is a foodborne bacterial pathogen that causes listeriosis, a severe infection that manifests as bacteremia and meningo-encephalitis mostly in immunocompromised individuals, and maternal-fetal infection. A critical pathogenic determinant of Lm relies on its ability to actively cross the intestinal barrier, disseminate systemically and cross the blood-brain and placental barriers. Here we illustrate how Lm both evades innate immunity, favoring its dissemination in host tissues, and triggers innate immune defenses that participate to its control.
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Submitted on : Friday, July 9, 2021 - 5:00:46 PM
Last modification on : Thursday, July 22, 2021 - 3:54:02 PM

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PASTEUR | UP-SANTE | UNIV-PARIS

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Claire Maudet, Sylvain Levallois, Olivier Disson, Marc Lecuit. Innate immune responses to Listeria in vivo. Current Opinion in Microbiology, Elsevier, 2021, 59, pp.95-101. ⟨10.1016/j.mib.2020.11.006⟩. ⟨pasteur-03276950⟩

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