Innate immune responses to Listeria in vivo

Claire Maudet (1) , Sylvain Levallois (1, 2) , Olivier Disson (1) , Marc Lecuit (1, 2, 3, 4, 5, 6, 7)

1 Biologie des Infections - Biology of Infection
2 UPCité - Université Paris Cité
3 CNRL - Centre National de Référence Listeria - National Reference Center Listeria
4 CC-OMS / WHO-CC - Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria
5 CHU Necker - Enfants Malades [AP-HP]
6 Service des Maladies infectieuses et tropicales [CHU Necker]
7 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)

Listeria monocytogenes (Lm) is a foodborne bacterial pathogen that causes listeriosis, a severe infection that manifests as bacteremia and meningo-encephalitis mostly in immunocompromised individuals, and maternal-fetal infection. A critical pathogenic determinant of Lm relies on its ability to actively cross the intestinal barrier, disseminate systemically and cross the blood-brain and placental barriers. Here we illustrate how Lm both evades innate immunity, favoring its dissemination in host tissues, and triggers innate immune defenses that participate to its control.

Domains: Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Microbiology and Parasitology; Bacteriology

Claire Maudet, Sylvain Levallois, Olivier Disson, Marc Lecuit. Innate immune responses to Listeria in vivo. Current Opinion in Microbiology, 2021, 59, pp.95-101. ⟨10.1016/j.mib.2020.11.006⟩. ⟨pasteur-03276950⟩