A High-Resolution Microsatellite Map of the Mouse Genome

Michael Rhodes (1) , Richard Straw (1) , Supem Fernando (1) , Andrew Evans (1) , Tregaye Lacey (1) , Andrew Dearlove (1) , John Greystrong (1) , Joanne Walker (1) , Paula Watson (1) , Paul Weston (1) , Maria Kelly (1) , Dilip Taylor (1) , Keith Gibson (1) , Chris Mundy (1) , Franck Bourgade (2) , Christophe Poirier (2) , Dominique Simon (2) , Ana Lucia Bueno Brunialti (2) , Xavier Montagutelli (2) , Jean-Louis Guénet (2) , Andy Haynes (3) , Steve D.M. Brown (3)

1 HGMP - United Kingdom Human Genome Mapping Project Resource Centre [Hinxton]
2 IP - Institut Pasteur [Paris]
3 MRC Harwell - Medical Research Coucil Harwell [Oxford, UK]

The European Collaborative Interspecific Backcross (EUCIB) resource was constructed for the purposes of high-resolution genetic mapping of the mouse genome (). The large Mus spretus/C57BL/6 backcross of 982 progeny has a genetic resolution of 0.3 cM at the 95% confidence level ( approximately 500 kb in the mouse genome). We have used the EUCIB mapping resource to develop a genome-wide high-resolution genetic map incorporating 3368 microsatellites. The microsatellites are distributed among 2302 genetically separated bins with 1.46 markers per bin on average. Average bin separation is 0.61 cM. This high-resolution genetic map will aid the construction of a robust physical map of the mouse genome.

Domaines: Sciences du Vivant [q-bio]

Michael Rhodes, Richard Straw, Supem Fernando, Andrew Evans, Tregaye Lacey, et al.. A High-Resolution Microsatellite Map of the Mouse Genome. Genome Research, 1998, 8 (5), pp.531-542. ⟨10.1101/gr.8.5.531⟩. ⟨pasteur-03274125⟩