Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells - Archive ouverte HAL Access content directly
Journal Articles Journal of Bacteriology Year : 2019

Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells

(1, 2) , (3) , (4, 5) , (2) , (5, 2, 1)
1
2
3
4
5

Abstract

Streptococcus gallolyticus is an opportunistic pathogen responsible for septicemia and endocarditis in the elderly and is also strongly associated with colorectal cancer. S. gallolyticus can form biofilms, express specific pili to colonize the host tissues, and produce a specific bacteriocin allowing killing of commensal bacteria in the murine colon. Nevertheless, how the expression of these colonization factors is regulated remains largely unknown. Here, we show that c-di-AMP plays pleiotropic roles in S. gallolyticus , controlling the tolerance to osmotic stress, cell size, biofilm formation on abiotic surfaces, adherence and cell aggregation on human intestinal cells, expression of Pil3 pilus, and production of bacteriocin. This study indicates that c-di-AMP may constitute a key regulatory molecule for S. gallolyticus host colonization and pathogenesis.
Fichier principal
Vignette du fichier
JB.00597-18.pdf (2.34 Mo) Télécharger le fichier

Dates and versions

pasteur-03262262 , version 1 (16-06-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Wooi Keong Teh, Shaynoor Dramsi, Tim Tolker-Nielsen, Liang Yang, Michael Givskov. Increased Intracellular Cyclic di-AMP Levels Sensitize Streptococcus gallolyticus subsp. gallolyticus to Osmotic Stress and Reduce Biofilm Formation and Adherence on Intestinal Cells. Journal of Bacteriology, 2019, 201 (6), pp.e00597-18. ⟨10.1128/JB.00597-18⟩. ⟨pasteur-03262262⟩

Collections

PASTEUR CNRS
17 View
22 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More