Skip to Main content Skip to Navigation
Journal articles

Operative list of genes associated with autism and neurodevelopmental disorders based on database review

Abstract : The genetics of neurodevelopmental disorders (NDD) has made tremendous progress during the last few decades with the identification of more than 1,500 genes associated with conditions such as intellectual disability and autism. The functional roles of these genes are currently studied to uncover the biological mechanisms influencing the clinical outcome of the mutation carriers. To integrate the data, several databases and curated gene lists have been generated. Here, we provide an overview of the main databases focusing on the genetics of NDD, that are widely used by the medical and scientific communities, and extract a list of high confidence NDD genes (HC-NDD). This gene set can be used as a first filter for interpreting large scale omics dataset or for diagnostic purposes. Overall HC-NDD genes (N = 1,586) are expressed at very early stages of fetal brain development and enriched in several biological pathways such as chromosome organization, cell cycle, metabolism and synaptic function. Among those HC-NDD genes, 204 (12,9%) are listed in the synaptic gene ontology SynGO and are enriched in genes expressed after birth in the cerebellum and the cortex of the human brain. Finally, we point at several limitations regarding the relatively poor standardized information available, especially on the carriers of the mutations. Progress on the phenotypic characterization and genetic profiling of the carriers will be crucial to improve our knowledge on the biological mechanisms and on risk and protective factors for NDD.
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03261328
Contributor : Freddy Cliquet <>
Submitted on : Tuesday, June 15, 2021 - 4:02:27 PM
Last modification on : Tuesday, July 13, 2021 - 3:15:06 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-10-29

Please log in to resquest access to the document

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

Claire Leblond, Thuy-Linh Le, Simon Malesys, Freddy Cliquet, Anne-Claude Tabet, et al.. Operative list of genes associated with autism and neurodevelopmental disorders based on database review. Molecular and Cellular Neuroscience, Elsevier, 2021, 113, pp.103623. ⟨10.1016/j.mcn.2021.103623⟩. ⟨pasteur-03261328⟩

Share

Metrics

Record views

39