Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats

Benoît de Thoisy (1, 2) , Olivier Duron (3, 4) , Loïc Epelboin (5) , Lise Musset (6, 7, 2, 8) , Philippe Quénel (9, 10) , Benjamin Roche (11, 3) , Florian Binetruy (4) , Sébastien Briolant (12, 13) , Luisiane Carvalho (14) , Agathe Chavy (1) , Pierre Couppié (5) , Magalie Pierre Demar (15, 16) , Maylis Douine (17) , I. Dusfour (18) , Sébastien Gourbière (19) , Yanouk Epelboin (20, 2) , Claude Flamand (21, 22, 2) , Alain Franc (23, 24) , Marine Ginouvès (16, 25) , Emeline S Houël (26) , Arthur Kocher (27, 28) , Anne Lavergne (1, 2) , Paul Le Turnier (29, 30) , Luana Mathieu (2, 8, 6, 7) , Jérôme Murienne (28) , Mathieu Nacher (17, 5) , Roxane Schaub (15, 16, 17) , Stéphane Pelleau (9, 31, 32, 2, 8) , Ghislaine Prévot (15, 16) , Dominique Rousset (1, 2) , Emmanuel Roux (33, 34) , Stanislas Talaga (4, 20) , Pauline Thill (35, 36) , Sourakhata Tirera (1, 2) , Jean-François Guégan (4, 37)

1 Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française]
2 Institut Pasteur de la Guyane
3 CREES - Centre de Recherche en Ecologie et Evolution de la Santé
4 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
5 Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
6 CNR - laboratoire associé - Centre National de Référence du Paludisme [Cayenne, Guyane française]
7 CCOMS - Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française]
8 Laboratoire de Parasitologie [Cayenne, Guyane française]
9 Irset - Institut de recherche en santé, environnement et travail
10 EHESP - École des Hautes Études en Santé Publique [EHESP]
11 MIVEGEC-CREEC - Centre de Recherches Ecologiques et Evolutives sur le Cancer
12 VITROME - Vecteurs - Infections tropicales et méditerranéennes
13 IRBA - Institut de Recherche Biomédicale des Armées [Antenne Marseille]
14 Santé publique France Guyane
15 UG - Université de Guyane
16 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
17 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane
18 Département de Santé Globale - Department Global Health
19 LGDP - Laboratoire Génome et développement des plantes
20 Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française]
21 Unité d'Epidémiologie [Cayenne, Guyane française]
22 Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases
23 BioGeCo - Biodiversité, Gènes & Communautés
24 PLEIADE - from patterns to models in computational biodiversity and biotechnology
25 TBIP - Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille]
26 UMR ECOFOG - Ecologie des forêts de Guyane
27 MPI-SHH - Max Planck Institute for the Science of Human History
28 EDB - Evolution et Diversité Biologique
29 CIC Nantes - Centre d’Investigation Clinique de Nantes
30 CHU Nantes - Centre hospitalier universitaire de Nantes
31 Malaria : parasites et hôtes - Malaria : parasites and hosts
32 IP - Institut Pasteur [Paris]
33 UMR 228 Espace-Dev, Espace pour le développement
34 LMI Sentinela [Rio de Janeiro]
35 Service Universitaire des Maladies Infectieuses et du Voyageur [Tourcoing]
36 Centre Hospitalier Gustave Dron [Tourcoing]
37 UMR ASTRE - Animal, Santé, Territoires, Risques et Ecosystèmes

French Guiana is a European ultraperipheric region located on the northern Atlantic coast of South America. It constitutes an important forested region for biological conservation in the Neotropics. Although very sparsely populated, with its inhabitants mainly concentrated on the Atlantic coastal strip and along the two main rivers, it is marked by the presence and development of old and new epidemic disease outbreaks, both research and health priorities. In this review paper, we synthetize 15 years of multidisciplinary and integrative research at the interface between wildlife, ecosystem modification, human activities and sociodemographic development, and human health. This study reveals a complex epidemiological landscape marked by important transitional changes, facilitated by increased interconnections between wildlife, land-use change and human occupation and activity, human and trade transportation, demography with substantial immigration, and identified vector and parasite pharmacological resistance. Among other French Guianese characteristics, we demonstrate herein the existence of more complex multi-host disease life cycles than previously described for several disease systems in Central and South America, which clearly indicates that today the greater promiscuity between wildlife and humans due to demographic and economic pressures may offer novel settings for microbes and their hosts to circulate and spread. French Guiana is a microcosm that crystallizes all the current global environmental, demographic and socioeconomic change conditions, which may favor the development of ancient and future infectious diseases.

Keywords: Anthropogenic pressures; Emerging and reemerging infectious diseases; Epidemiologic transition; French Guiana; Global change

Domains: Life Sciences [q-bio]; Infectious diseases; Emerging diseases; Global Changes

Benoît de Thoisy, Olivier Duron, Loïc Epelboin, Lise Musset, Philippe Quénel, et al.. Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats. Infection, Genetics and Evolution, 2021, 93, pp.104916. ⟨10.1016/j.meegid.2021.104916⟩. ⟨pasteur-03261181⟩