Social and non-social autism symptoms and trait domains are genetically dissociable - Archive ouverte HAL Access content directly
Journal Articles Communications Biology Year : 2019

Social and non-social autism symptoms and trait domains are genetically dissociable

(1) , (2) , (3) , (2) , (2) , (2, 4) , (5) , (5, 6) , (1, 7) , (8, 9) , (8, 9) , (5) , , (10) , (2) , (1)
1
2
3
4
5
6
7
8
9
10
Varun Warrier
  • Function : Correspondent author
  • PersonId : 1015596

Connectez-vous pour contacter l'auteur
23andme Research Team
  • Function : Author
David A. Hinds
  • Function : Author

Abstract

The core diagnostic criteria for autism comprise two symptom domainssocial and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to suggest that these two domains are dissociable, though this hypothesis has not yet been tested using molecular genetics. We test this using a genome-wide association study (N = 51,564) of a non-social trait related to autism, systemising, defined as the drive to analyse and build systems. We demonstrate that systemising is heritable and genetically correlated with autism. In contrast, we do not identify significant genetic correlations between social autistic traits and systemising. Supporting this, polygenic scores for systemising are significantly and positively associated with restricted and repetitive behaviour but not with social difficulties in autistic individuals. These findings strongly suggest that the two core domains of autism are genetically dissociable, and point at how to fractionate the genetics of autism.
Fichier principal
Vignette du fichier
s42003-019-0558-4.pdf (1.7 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03261098 , version 1 (15-06-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Varun Warrier, Roberto Toro, Hyejung Won, Claire S. Leblond, Freddy Cliquet, et al.. Social and non-social autism symptoms and trait domains are genetically dissociable. Communications Biology, 2019, 2 (1), pp.328. ⟨10.1038/s42003-019-0558-4⟩. ⟨pasteur-03261098⟩
20 View
27 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More