HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Camila Tenorio França 1, 2 Michael White 1, 3 Wen-Qiang He 2, 1 Jessica Hostetler 4, 5 Jessica Brewster 1 Gabriel Frato 6 Indu Malhotra 6 Jakub Gruszczyk 1 Christele Huon 7 Enmoore Lin 8 Benson Kiniboro 8 Anjali Yadava 9 Peter Siba 8 Mary Galinski 10 Julie Healer 2, 1 Chetan Chitnis 7, 11 Alan Cowman 2, 1 Eizo Takashima 9 Takafumi Tsuboi 12 Wai-Hong Tham 2, 1 Rick Fairhurst 5 Julian Rayner 4 Christopher King 6 Ivo Mueller 1, 2, 7, 13, *
* Corresponding author
1 WEHI - The Walter and Eliza Hall Institute of Medical Research
2 University of Melbourne
3 Imperial College London
4 The Wellcome Trust Sanger Institute [Cambridge]
5 Laboratory of Malaria and Vector Research [Rockville]
6 Case Western Reserve University [Cleveland]
7 Malaria : parasites et hôtes - Malaria : parasites and hosts
8 PNGIMR - Papua New Guinea Institute for Medical Research
9 Walter Reed Army Institute of Research
10 Emory University [Atlanta, GA]
11 ICGEB - International Centre for Genetic Engineering and Biotechnology [New Delhi]
12 Ehime University [Matsuyama]
13 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
Abstract : The study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1–3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44–0.74, p<0.001–0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.
Keywords : IgG antibody Plasmodium vivax clinical malaria epidemiology global health natural immunity protection vaccine
Document type :
Journal articles
Complete list of metadata
https://hal-pasteur.archives-ouvertes.fr/pasteur-03260305
Contributor : Christele Huon Connect in order to contact the contributor
Submitted on : Monday, June 14, 2021 - 5:57:05 PM
Last modification on : Thursday, April 7, 2022 - 10:10:45 AM
Long-term archiving on: : Thursday, September 16, 2021 - 8:25:35 AM

File

Vignette du document
elife-28673-v2.pdf
Publication funded by an institution

Licence

Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

PASTEUR

Citation

Camila Tenorio França, Michael White, Wen-Qiang He, Jessica Hostetler, Jessica Brewster, et al.. Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development. eLife, eLife Sciences Publication, 2017, 6, pp.e28673. ⟨10.7554/eLife.28673⟩. ⟨pasteur-03260305⟩

Export

BibTeX TEI DC DCterms EndNote Datacite

Share

Metrics

Record views

7

Files downloads

19