Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Fabien Aubry; Stéphanie Dabo; Caroline Manet; Igor Filipović; Noah Rose; Elliott Miot; Daria Martynow; Artem Baidaliuk; Sarah Merkling; Laura Dickson; Anna Crist; Victor Anyango; Claudia Romero-Vivas; Anubis Vega-Rúa; I. Dusfour; Davy Jiolle; Christophe Paupy; Martin Mayanja; Julius Lutwama; Alain Kohl; Veasna Duong; Alongkot Ponlawat; Massamba Sylla; Jewelna Akorli; Sampson Otoo; Joel Lutomiah; Rosemary Sang; John-Paul Mutebi; Van-Mai Cao-Lormeau; Richard Jarman; Cheikh Diagne; Oumar Faye; Ousmane Faye; Amadou Sall; Carolyn Mcbride; Xavier Montagutelli; Gordana Rašić; Louis Lambrechts

doi:10.1126/science.abd3663

Journal articles

Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Fabien Aubry ¹ Stéphanie Dabo ¹ Caroline Manet ² Igor Filipović ³ Noah Rose ⁴ Elliott Miot ^{1, 5} Daria Martynow ¹ Artem Baidaliuk ^{1, 5} Sarah Merkling ¹ Laura Dickson ¹ Anna Crist ¹ Victor Anyango ¹ Claudia Romero-Vivas ⁶ Anubis Vega-Rúa ⁷ I. Dusfour ⁸ Davy Jiolle ^{9, 10} Christophe Paupy ^{9, 10} Martin Mayanja ¹¹ Julius Lutwama ¹¹ Alain Kohl ¹² Veasna Duong ¹³ Alongkot Ponlawat ¹⁴ Massamba Sylla ¹⁵ Jewelna Akorli ¹⁶ Sampson Otoo ¹⁶ Joel Lutomiah ¹⁷ Rosemary Sang ¹⁷ John-Paul Mutebi ¹⁸ Van-Mai Cao-Lormeau ¹⁹ Richard Jarman ²⁰ Cheikh Diagne ²¹ Oumar Faye ²¹ Ousmane Faye ²¹ Amadou Sall ²¹ Carolyn Mcbride ⁴ Xavier Montagutelli ² Gordana Rašić ³ Louis Lambrechts ^{1, *}

* Corresponding author

1 IVI - Interactions Virus-Insectes - Insect-Virus Interactions

2 Génétique de la souris - Mouse Genetics

3 QIMR Berghofer Medical Research Institute

4 Princeton University

5 Collège doctoral [Sorbonne universités]

6 Universidad del Norte, Barranquilla

7 TReD-Path - Unité Transmission, Réservoir et Diversité des Pathogènes [Pasteur Guadeloupe, France]

8 Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française]

9 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle

10 CIRMF - Centre International de Recherches Médicales de Franceville

11 UVRI - Uganda Virus Research Institute

12 MRC - University of Glasgow Centre for Virus Research

13 Unité de Virologie / Virology Unit [Phnom Penh]

14 AFRIMS - Armed Forces Research Institute of Medical Sciences [Bangkok]

15 UCAD - Université Cheikh Anta Diop [Dakar, Sénégal]

16 University of Ghana

17 KEMRI - Kenya Medical Research Institute

18 Centers for Disease Control and Prevention

19 ILM - Institut Louis Malardé [Papeete]

20 Walter Reed Army Institute of Research

21 Arbovirus et Virus de Fièvres Hémorragiques

Abstract : The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

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https://hal-pasteur.archives-ouvertes.fr/pasteur-03260288
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Submitted on : Monday, June 14, 2021 - 5:41:52 PM
Last modification on : Tuesday, July 13, 2021 - 3:29:27 AM

Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

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Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

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