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Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Fabien Aubry 1 Stéphanie Dabo 1 Caroline Manet 2 Igor Filipović 3 Noah H. Rose 4 Elliott F. Miot 1, 5 Daria Martynow 1 Artem Baidaliuk 1, 5 Sarah H. Merkling 1 Laura B. Dickson 1 Anna B. Crist 1 Victor O. Anyango 1 Claudia M. Romero-Vivas 6 Anubis Vega-Rúa 7 I. Dusfour 8 Davy Jiolle 9, 10 Christophe Paupy 9, 10 Martin N. Mayanja 11 Julius J. Lutwama 11 Alain Kohl 12 Veasna Duong 13 Alongkot Ponlawat 14 Massamba Sylla 15 Jewelna Akorli 16 Sampson Otoo 16 Joel Lutomiah 17 Rosemary Sang 17 John-Paul Mutebi 18 Van-Mai Cao-Lormeau 19 Richard G. Jarman 20 Cheikh T. Diagne 21 Oumar Faye 21 Ousmane Faye 21 Amadou A. Sall 21 Carolyn S. Mcbride 4 Xavier Montagutelli 2 Gordana Rašić 3 Louis Lambrechts 1, * 
Abstract : The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.
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Submitted on : Monday, June 14, 2021 - 5:41:52 PM
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Fabien Aubry, Stéphanie Dabo, Caroline Manet, Igor Filipović, Noah H. Rose, et al.. Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations. Science, American Association for the Advancement of Science (AAAS), 2020, 370 (6519), pp.991-996. ⟨10.1126/science.abd3663⟩. ⟨pasteur-03260288⟩



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