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Energy metabolism | 2-Oxoglutarate Dehydrogenase Complex

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Abstract

2-Oxoglutarate dehydrogenase (ogdh gene) is an ubiquitous enzyme with additional isoenzymes (ogdhl and dhtkd1 genes) characterized in animals. Using thiamine (vitamin B1) diphosphate, the isoenzymes catalyze oxidative decarboxylation of 2-oxoglutarate or 2-oxoadipate. The coupled generation of succinyl- or glutaryl-CoA and NADH requires self-assembled multienzyme complexes. The complex core is formed by dihydrolipoyl succinyltransferase (dlst gene), binding multiple copies of 2-oxoglutarate dehydrogenase and dihydrolipoamide dehydrogenase (dldh gene). The components stoichiometry depends on the complex sources and/or isolation conditions. Components of the 2-oxoglutarate dehydrogenase complex also catalyze carboligase reaction or reaction with molecular oxygen, which are of potential physiological significance.
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Dates and versions

pasteur-03259560 , version 1 (14-06-2021)

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Victoria Bunik, Tristan Wagner, Marco Bellinzoni. Energy metabolism | 2-Oxoglutarate Dehydrogenase Complex. Joseph Jez. Encyclopedia of Biological Chemistry III, Third edition, vol.1, Elsevier, pp.259-271, 2021, 978-0-12-822040-5. ⟨10.1016/B978-0-12-819460-7.00127-4⟩. ⟨pasteur-03259560⟩
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