Energy metabolism | 2-Oxoglutarate Dehydrogenase Complex

Victoria Bunik (1, 2) , Tristan Wagner (3) , Marco Bellinzoni (4)

1 Department of Chemistry, Lomonosov Moscow State University
2 Sechenov First Moscow State Medical University
3 Max Planck Institute for Marine Microbiology
4 Microb. Struc. (UMR_3528 / U-Pasteur_5) - Microbiologie structurale - Structural Microbiology

2-Oxoglutarate dehydrogenase (ogdh gene) is an ubiquitous enzyme with additional isoenzymes (ogdhl and dhtkd1 genes) characterized in animals. Using thiamine (vitamin B1) diphosphate, the isoenzymes catalyze oxidative decarboxylation of 2-oxoglutarate or 2-oxoadipate. The coupled generation of succinyl- or glutaryl-CoA and NADH requires self-assembled multienzyme complexes. The complex core is formed by dihydrolipoyl succinyltransferase (dlst gene), binding multiple copies of 2-oxoglutarate dehydrogenase and dihydrolipoamide dehydrogenase (dldh gene). The components stoichiometry depends on the complex sources and/or isolation conditions. Components of the 2-oxoglutarate dehydrogenase complex also catalyze carboligase reaction or reaction with molecular oxygen, which are of potential physiological significance.

Keywords: 2-oxoglutarate dehydrogenase; Carboligase; DHTKD1 or E1a; Dihydrolipoamide dehydrogenase; Dihydrolipoamide succinyl transferase; DLDH or DLD or E3; DLST or E2o or ODO2; Multienzyme complex; OGDH or E1o or ODO1 or KGD; OGDHL or E1o; Side reaction with molecular oxygen; Thiamine diphosphate; Vitamin

Domains: Biochemistry [q-bio.BM]

Victoria Bunik, Tristan Wagner, Marco Bellinzoni. Energy metabolism | 2-Oxoglutarate Dehydrogenase Complex. Joseph Jez. Encyclopedia of Biological Chemistry III, Third edition, vol.1, Elsevier, pp.259-271, 2021, 978-0-12-822040-5. ⟨10.1016/B978-0-12-819460-7.00127-4⟩. ⟨pasteur-03259560⟩