Stress by Heat Shock Induces Massive Down Regulation of Genes and Allows Differential Allelic Expression of the Gal/GalNAc Lectin in Entamoeba histolytica

Christian Weber (1) , Ghislaine Guigon (2) , Christiane Bouchier (2) , L. Frangeul (2) , Sandrine Moreira (2) , Odile Sismeiro (2) , Catherine Gouyette (2) , David Mirelman (3) , Jean Yves Coppee (2) , Nancy Guillén (1)

1 Biologie Cellulaire du Parasitisme
2 Génopole
3 Weizmann Institute of Science [Rehovot, Israël]

Gene expression analysis by microarray assay revealed that when exposed to stress, Entamoeba histolytica exhibits a specific heat shock response, together with a dramatic overall reduction in gene transcription as well as differential allelic expression of key genes participating in virulence, such as the galactose/ N -acetylgalactosamine (Gal/GalNAc) lectin.

Domains: Bioinformatics [q-bio.QM]; Genomics [q-bio.GN]; Virology

Christian Weber, Ghislaine Guigon, Christiane Bouchier, L. Frangeul, Sandrine Moreira, et al.. Stress by Heat Shock Induces Massive Down Regulation of Genes and Allows Differential Allelic Expression of the Gal/GalNAc Lectin in Entamoeba histolytica. Eukaryotic Cell, 2006, 5 (5), pp.871-875. ⟨10.1128/EC.5.5.871-875.2006⟩. ⟨pasteur-03252368⟩