Enterovirus A71 Infection

Kum Thong Wong (1) , Kien Chai Ong (1) , Thérèse Couderc (2) , Marc Lecuit (2, 3, 4, 5, 6)

1 UM - University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie]
2 Biologie des Infections - Biology of Infection
3 UPCité - Université Paris Cité
4 Hôpital Necker - Enfants Malades [AP-HP]
5 Service des Maladies infectieuses et tropicales [CHU Necker]
6 Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)

Enterovirus A71 (EV-A71) belongs to the species group A in the Enterovirus genus within the Picornaviridae family. Although usually causes self-limiting hand, foot, and mouth disease or herpangina, it may also rarely cause severe neurological complications such as acute flaccid paralysis (AFP) or encephalomyelitis whose outcome is often fatal. Severe disease has been observed in young children during the large outbreaks that occurred in the Asia Pacific region in the two last decades. In this chapter, we describe the microbiological, epidemiological, clinical, and pathological features of EV-A71 and discuss the pathogenesis of the disease

Mots clés: enterovirus A71 (EV-A71); Picornaviridae; encephalomyelitis; neuronotropism

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Maladies infectieuses; Microbiologie et Parasitologie; Santé publique et épidémiologie

Kum Thong Wong, Kien Chai Ong, Thérèse Couderc, Marc Lecuit. Enterovirus A71 Infection. Fabrice Chrétien, Kum Thong Wong, Leroy R. Sharer, Catherine (Katy) Keohane, Françoise Gray. Infections of the Central Nervous System: Pathology and Genetics, Wiley, Chap 22, 2020, 978-1-119-46779-3. ⟨10.1002/9781119467748.ch22⟩. ⟨pasteur-03246290⟩