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Using ProteoCombiner to integrate bottom-up and top-down proteomics data to improve proteoform identification
Abstract : Here we present a high-performance software for proteome analysis that combines different mass spectrometric approaches, such as, top-down for intact protein analyses and bottom-up, for proteolytic fragment characterization. ProteoCombiner capitalizes on the data arising from different experiments and proteomics search engines and presents the results in a user-friendly manner. Our tool also provides a rapid and easy visualization, manual validation and comparison of the identified proteoform sequences, including post-translational modifications (PTM) characterization. Thus, ProteoCombiner is recommended for studies dealing with different proteomics strategies, in order to increase confidence in proteoform identification including PTMs.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03243560
Contributor : Quentin Giai Gianetto Connect in order to contact the contributor
Submitted on : Friday, November 5, 2021 - 2:52:16 PM
Last modification on : Wednesday, January 19, 2022 - 1:44:01 PM
Contributor : Quentin Giai Gianetto Connect in order to contact the contributor
Submitted on : Friday, November 5, 2021 - 2:52:16 PM
Last modification on : Wednesday, January 19, 2022 - 1:44:01 PM
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Distributed under a Creative Commons Attribution 4.0 International License