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Using ProteoCombiner to integrate bottom-up and top-down proteomics data to improve proteoform identification

Abstract : Here we present a high-performance software for proteome analysis that combines different mass spectrometric approaches, such as, top-down for intact protein analyses and bottom-up, for proteolytic fragment characterization. ProteoCombiner capitalizes on the data arising from different experiments and proteomics search engines and presents the results in a user-friendly manner. Our tool also provides a rapid and easy visualization, manual validation and comparison of the identified proteoform sequences, including post-translational modifications (PTM) characterization. Thus, ProteoCombiner is recommended for studies dealing with different proteomics strategies, in order to increase confidence in proteoform identification including PTMs.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03243560
Contributor : Quentin Giai Gianetto Connect in order to contact the contributor
Submitted on : Friday, November 5, 2021 - 2:52:16 PM
Last modification on : Tuesday, April 12, 2022 - 4:30:02 PM
Long-term archiving on: : Sunday, February 6, 2022 - 7:12:08 PM

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Distributed under a Creative Commons Attribution 4.0 International License

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Diogo Borges Lima, Mathieu Dupré, Magalie Duchateau, Quentin Giai Gianetto, Martial Jean-Pierre Rey, et al.. Using ProteoCombiner to integrate bottom-up and top-down proteomics data to improve proteoform identification. 2021. ⟨pasteur-03243560⟩

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