Skip to Main content Skip to Navigation
Preprints, Working Papers, ...

Using ProteoCombiner to integrate bottom-up and top-down proteomics data to improve proteoform identification

Abstract : Here we present a high-performance software for proteome analysis that combines different mass spectrometric approaches, such as, top-down for intact protein analyses and bottom-up, for proteolytic fragment characterization. ProteoCombiner capitalizes on the data arising from different experiments and proteomics search engines and presents the results in a user-friendly manner. Our tool also provides a rapid and easy visualization, manual validation and comparison of the identified proteoform sequences, including post-translational modifications (PTM) characterization. Thus, ProteoCombiner is recommended for studies dealing with different proteomics strategies, in order to increase confidence in proteoform identification including PTMs.
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03243560
Contributor : Quentin Giai Gianetto <>
Submitted on : Monday, May 31, 2021 - 4:38:43 PM
Last modification on : Wednesday, June 23, 2021 - 2:18:12 PM

Links full text

Identifiers

Collections

Citation

Diogo Borges Lima, Mathieu Dupré, Magalie Duchateau, Quentin Giai Gianetto, Martial Rey, et al.. Using ProteoCombiner to integrate bottom-up and top-down proteomics data to improve proteoform identification. 2021. ⟨pasteur-03243560⟩

Share

Metrics

Record views

40