Skip to Main content Skip to Navigation
Journal articles

Cryptococcus gattii in Patients with Lymphoid Neoplasms: An Illustration of Evolutive Host–Fungus Interactions

Abstract : Recent outbreaks of Cryptococcus gattii (CG) infections in North America have sparked renewed interest in the pathogenic potential of CG, and have underscored notable differences with Cryptococcus neoformans in terms of geographic distribution, pathogen virulence, and host susceptibility. While cases of CG are increasingly reported in patients with a wide variety of underlying conditions, only very few have been reported in patients with lymphoid neoplasms. Herein, we report a case of autochthonous CG meningitis in a patient receiving ibrutinib for chronic lymphocytic leukemia in France, and review available data on the clinical epidemiology of CG infections in patients with lymphoid neoplasms. We also summarise recent data on the host responses to CG infection, as well as the potential management pitfalls associated with its treatment in the haematological setting. The clinical epidemiology, clinical presentation, and course of disease during infections caused by CG involve complex interactions between environmental exposure to CG, infecting genotype, pathogen virulence factors, host susceptibility, and host immune responses. Future treatment guidelines should address the challenges associated with the management of antifungal treatments in the onco-haematological setting and the potential drug-drug interactions.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03243554
Contributor : Marie Desnos-Ollivier <>
Submitted on : Monday, May 31, 2021 - 4:37:09 PM
Last modification on : Friday, July 23, 2021 - 3:41:43 AM

File

jof-07-00212.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Olivier Paccoud, Marie-Elisabeth Bougnoux, Marie Desnos-Ollivier, Bruno Varet, Olivier Lortholary, et al.. Cryptococcus gattii in Patients with Lymphoid Neoplasms: An Illustration of Evolutive Host–Fungus Interactions. Journal of Fungi, MDPI, 2021, 7 (3), pp.212. ⟨10.3390/jof7030212⟩. ⟨pasteur-03243554⟩

Share

Metrics

Record views

47

Files downloads

112