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Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”

Abstract : Taniguchi et al . (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about the validity of some of the conclusions.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03242901
Contributor : Pierre Bruhns <>
Submitted on : Monday, May 31, 2021 - 12:29:42 PM
Last modification on : Monday, June 21, 2021 - 1:40:03 PM

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Jasper Kamphuis, William Worrall, Julien Stackowicz, Aurélie Mougel, Emilie Mauré, et al.. Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”. Science, American Association for the Advancement of Science, 2021, 372 (6538), pp.eabf2022. ⟨10.1126/science.abf2022⟩. ⟨pasteur-03242901⟩

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