Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression” - Archive ouverte HAL Access content directly
Journal Articles Science Year : 2021

Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”

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Abstract

Taniguchi et al . (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about the validity of some of the conclusions.
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pasteur-03242901 , version 1 (31-05-2021)

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Jasper B J Kamphuis, William P M Worrall, Julien Stackowicz, Aurélie Mougel, Emilie Mauré, et al.. Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”. Science, 2021, 372 (6538), pp.eabf2022. ⟨10.1126/science.abf2022⟩. ⟨pasteur-03242901⟩
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