Skip to Main content Skip to Navigation
Journal articles

Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers

Abstract : Rare individuals can naturally clear chronic hepatitis B virus (HBV) infection and acquire protection from reinfection as conferred by vaccination. To examine the protective humoral response against HBV, we cloned and characterized human antibodies specific to the viral surface glycoproteins (HBsAg) from memory B cells of HBV vaccinees and controllers. We found that human HBV antibodies are encoded by a diverse set of immunoglobulin genes and recognize various conformational HBsAg epitopes. Strikingly, HBsAg-specific memory B cells from natural controllers mainly produced neutralizing antibodies able to cross-react with several viral genotypes. Furthermore, monotherapy with the potent broadly neutralizing antibody Bc1.187 suppressed viremia in vivo in HBV mouse models and led to post-therapy control of the infection in a fraction of animals. Thus, human neutralizing HBsAg antibodies appear to play a key role in the spontaneous control of HBV and represent promising immunotherapeutic tools for achieving HBV functional cure in chronically infected humans.
Complete list of metadata
Contributor : Maryline BOURGINE Connect in order to contact the contributor
Submitted on : Monday, May 31, 2021 - 11:43:06 AM
Last modification on : Wednesday, September 28, 2022 - 4:20:12 PM


Publication funded by an institution


Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License



Verena Hehle, Maxime Beretta, M Bourgine, Malika Ait-Goughoulte, Cyril Planchais, et al.. Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers. Journal of Experimental Medicine, Rockefeller University Press, 2020, 217 (10), pp.e20200840. ⟨10.1084/jem.20200840⟩. ⟨pasteur-03242779⟩



Record views


Files downloads