Detection of Hepatitis B Virus DNA in Pancreas, Kidney and Skin of Two Human Carriers of the Virus

Anne Dejean (1) , Claire Lugassy (1) , Serge Zafrani (2) , Pierre Tiollais (1) , Christian Brechot (1)

1 Recombinaison et Expression Génétique
2 Service d'Anatomopathologie [Hôpital Henri Mondor - APHP]

Using the Southern blot technique, we have analysed the presence and state of hepatitis B virus (HBV) DNA in non-hepatic tissue from two human HBV carriers. HBV DNA sequences were detected in the pancreas, kidney and skin, demonstrating HBV infection of these organs. Moreover, the restriction DNA patterns were consistent with the integration of these viral sequences into high molecular weight DNA. These results demonstrate that HBV infection is not restricted to the liver.

Mots clés: HBV DNA; non-hepatic infection; Southern blotting

Domaines: Sciences du Vivant [q-bio]

Anne Dejean, Claire Lugassy, Serge Zafrani, Pierre Tiollais, Christian Brechot. Detection of Hepatitis B Virus DNA in Pancreas, Kidney and Skin of Two Human Carriers of the Virus. Journal of General Virology, 1984, 65 (3), pp.651-655. ⟨10.1099/0022-1317-65-3-651⟩. ⟨pasteur-03238350⟩