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A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

Hugues de Thé 1 Agnès Marchio 1 Pierre Tiollais 1 Anne Dejean 1
1 Recombinaison et expression génétique
Institut Pasteur [Paris], INSERM - Institut National de la Santé et de la Recherche Médicale : U 163, CNRS - Centre National de la Recherche Scientifique : URA 271
Abstract : We have previously isolated from a human hepatocellular carcinoma a hepatitis B virus integration in a 147-base-pair cellular DNA fragment, similar to steroid- and c-erb-A/thyroid-hormone receptor genes. We have now cloned the corresponding complementary DNA from a human-liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which we have named hap, is similar to that of the DNA-binding hormone receptors. That is, it displays two highly conserved regions identified as the putative DNA-binding and hormone-binding domains of the c-erb A/steroid receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5-kilobase (kb) hap messenger RNA species which is undetectable in normal adult and fetal livers but present in all non-hepatic tissues analysed. The data suggest that the hap gene product may be a novel ligand-responsive regulatory protein whose inappropriate expression in liver may relate to the hepatocellular carcinogenesis.
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Submitted on : Thursday, May 27, 2021 - 9:20:07 AM
Last modification on : Thursday, July 22, 2021 - 1:29:13 PM

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Hugues de Thé, Agnès Marchio, Pierre Tiollais, Anne Dejean. A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature, Nature Publishing Group, 1987, 330 (6149), pp.667-670. ⟨10.1038/330667a0⟩. ⟨pasteur-03238341⟩

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