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A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus

Pascal Pineau 1 Agnès Marchio 1 Benoit Terris 1 Marie-Geneviève Mattei 2 Zhen-Xing Tu Pierre Tiollais 1 Anne Dejean 3, 1 
2 Unité de Physiopathologie Chromosomique
TIMONE - Hôpital de la Timone [CHU - APHM], INSERM - Institut National de la Santé et de la Recherche Médicale : U 242
Abstract : Integrated hepatitis B virus (HBV) DNA is found in the great majority of human hepatocellular carcinomas, suggesting that these viral integrations may be implicated in liver oncogenesis. Besides the insertional mutagenesis characterized in a few selected cases and the contribution of viral transactivators to cell transformation to malignancy, HBV has been shown to generate gross chromosomal rearrangements potentially involved in carcinogenesis. Here, we report a t(3;8) chromosomal translocation present in a hepatocellular carcinoma developed in noncirrhotic liver tissue. One side of the translocation, in 8p23, is shown to be in the vicinity of the carboxypeptidase N gene, a locus that is heavily transcribed in liver tissue and frequently deleted in hepatocellular carcinomas and other epithelial tumors. The other side of the translocation, in 3q27-29, is widely implicated in several types of translocations occurring in different malignancies, such as large-cell lymphomas. The present data strongly support a model in which HBV-induced chromosomal rearrangements play a key role during multistep liver oncogenesis.
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Submitted on : Thursday, May 27, 2021 - 8:38:32 AM
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Pascal Pineau, Agnès Marchio, Benoit Terris, Marie-Geneviève Mattei, Zhen-Xing Tu, et al.. A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus. Journal of Virology, American Society for Microbiology, 1996, 70 (10), pp.7280-7284. ⟨10.1128/JVI.70.10.7280-7284.1996⟩. ⟨pasteur-03238253⟩

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