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Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus

Abstract : The function of the subnuclear structure the promyelocytic leukaemia (PML) body is unclear largely because of the functional heterogeneity of its constituents. Here, we provide the evidence for a direct link between PML, higher-order chromatin organization and gene regulation. We show that PML physically and functionally interacts with the matrix attachment region (MAR)-binding protein, special AT-rich sequence binding protein 1 (SATB1) to organize the major histocompatibility complex (MHC) class I locus into distinct higher-order chromatin-loop structures. Interferon gamma (IFNgamma) treatment and silencing of either SATB1 or PML dynamically alter chromatin architecture, thus affecting the expression profile of a subset of MHC class I genes. Our studies identify PML and SATB1 as a regulatory complex that governs transcription by orchestrating dynamic chromatin-loop architecture.
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Submitted on : Wednesday, May 26, 2021 - 2:50:13 PM
Last modification on : Thursday, April 7, 2022 - 10:10:29 AM

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Pavan Kumar P., Oliver Bischof, Prabhat Kumar Purbey, Dimple Notani, Henning Urlaub, et al.. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nature Cell Biology, Nature Publishing Group, 2006, 9 (1), pp.45-56. ⟨10.1038/ncb1516⟩. ⟨pasteur-03236983⟩

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