SUMO, the Three Rs and Cancer

Jacob-Sebastian Seeler (1) , O. Bischof (1) , K. Nacerddine (1) , A. Dejean (1)

1 Organisation Nucléaire et Oncogenèse

SUMO modification (sumoylation) plays important roles in nucleo-cytoplasmic transport, maintenance of sub-nuclear architecture, the regulation of gene expression and in DNA replication, repair and recombination. Here we review recent evidence for SUMO's role in protecting genomic integrity at both the chromosomal and the DNA level. Furthermore, the involvement of sumoylation and of specific SUMO targets in cancer is discussed.

Keywords: Cellular Senescence; Sister Chromatid Cohesion; Bloom Syndrome; Stall Replication Fork; Sumo Pathway

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Biochemistry, Molecular Biology

Jacob-Sebastian Seeler, O. Bischof, K. Nacerddine, A. Dejean. SUMO, the Three Rs and Cancer. Pier Paolo Pandolfi; Peter K. Vogt. Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy, 313, Springer, pp.49-71, 2007, Current Topics in Microbiology and Immunology, 978-3-540-34594-7. ⟨10.1007/978-3-540-34594-7_4⟩. ⟨pasteur-03236978⟩