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Article Dans Une Revue Cell Cycle Année : 2007

SUMO is Growing Senescent

Résumé

Cellular senescence is an irreversible cell cycle arrest that curbs unrestrained, aberrant proliferation of mammalian cells and is now recognized as a prominent tumor suppressive mechanism. We have shown recently that the E3 SUMO ligase PIASy actively contributes to execution of the senescence program, thus, providing the first evidence for a direct role of SUMO modification in this process. Here, we discuss some of the implications for this novel connection and future directions to study in more detail the importance of the SUMO pathway in senescence and tumorigenesis.

Dates et versions

pasteur-03236941 , version 1 (26-05-2021)

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Oliver Bischof, Anne Dejean. SUMO is Growing Senescent. Cell Cycle, 2007, 6 (6), pp.677-681. ⟨10.4161/cc.6.6.4021⟩. ⟨pasteur-03236941⟩

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