Diversity in immunogenomics: the value and the challenge

Kerui Peng (1) , Yana Safonova (2, 3) , Mikhail Shugay (4, 5) , Alice B. Popejoy (6) , Oscar L. Rodriguez (3) , Felix Breden (7) , Petter Brodin (8, 9) , Amanda M. Burkhardt (1) , Carlos Bustamante (6) , Van-Mai Cao-Lormeau (10) , Martin M. Corcoran (8) , Darragh Duffy (11) , Macarena Fuentes-Guajardo (12) , Ricardo Fujita (13) , Victor Greiff (14) , Vanessa D. Jönsson (15) , Xiao Liu (16) , Lluis Quintana-Murci (17, 18) , Maura Rossetti (19) , Jianming Xie (1) , Gur Yaari (20) , Wei Zhang (21) , Malak S. Abedalthagafi (22) , Khalid O. Adekoya (23) , Rahaman A. Ahmed (23) , Wei-Chiao Chang (24, 25) , Clive Gray (26, 27) , Yusuke Nakamura (28) , William D. Lees (29) , Purvesh Khatri (6) , Houda Alachkar (1) , Cathrine Scheepers (30, 31) , Corey T. Watson (3) , Gunilla B. Karlsson Hedestam (8) , Serghei Mangul (1)

1 USC - University of Southern California
2 UC San Diego - University of California [San Diego]
3 University of Louisville
4 RAS - Russian Academy of Sciences [Moscow]
5 Pirogov Russian National Research Medical University
6 Stanford University
7 SFU.ca - Simon Fraser University
8 Karolinska Institutet [Stockholm]
9 Karolinska University Hospital [Stockholm]
10 ILM - Institut Louis Malardé [Papeete]
11 Immunologie Translationnelle - Translational Immunology lab
12 Universidad de Tarapaca
13 Universidad de San Martín de Porres
14 UiO - University of Oslo
15 Beckman Research Institute [Duarte, CA]
16 Tsinghua Shenzhen International Graduate School [Shenzhen]
17 Génétique Evolutive Humaine - Human Evolutionary Genetics
18 Collège de France - Chaire Génomique humaine et évolution
19 UCLA - University of California [Los Angeles]
20 Bar-Ilan University [Israël]
21 CUHK - City University of Hong Kong [Hong Kong]
22 KACST - King Abdulaziz City for Science and Technology [Riyadh]
23 University of Lagos
24 Taipei Medical University
25 TMU-ShuangHo Hospital [New Taipei City]
26 University of Cape Town
27 Groote Schuur Hospital, University of Cape Town, South Africa.
28 Japanese Foundation for Cancer Research [Tokyo, Japan]
29 Birkbeck College [University of London]
30 NICD - National Institute for Communicable Diseases [Johannesburg]
31 WITS - University of the Witwatersrand [Johannesburg]

Immunogenomics studies have been largely limited to individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations. Inclusion of a greater diversity of individuals in immunogenomics studies will substantially enhance our understanding of human immunology.

Domains: Immunology

Kerui Peng, Yana Safonova, Mikhail Shugay, Alice B. Popejoy, Oscar L. Rodriguez, et al.. Diversity in immunogenomics: the value and the challenge. Nature Methods, 2021, ⟨10.1038/s41592-021-01169-5⟩. ⟨pasteur-03236474⟩