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Diversity in immunogenomics: the value and the challenge

Kerui Peng 1 Yana Safonova 2, 3 Mikhail Shugay 4, 5 Alice B. Popejoy 6 Oscar L. Rodriguez 3 Felix Breden 7 Petter Brodin 8, 9 Amanda M. Burkhardt 1 Carlos Bustamante 6 Van-Mai Cao-Lormeau 10 Martin M. Corcoran 8 Darragh Duffy 11 Macarena Fuentes-Guajardo 12 Ricardo Fujita 13 Victor Greiff 14 Vanessa D. Jönsson 15 Xiao Liu 16 Lluis Quintana-Murci 17, 18 Maura Rossetti 19 Jianming Xie 1 Gur Yaari 20 Wei Zhang 21 Malak S. Abedalthagafi 22 Khalid O. Adekoya 23 Rahaman A. Ahmed 23 Wei-Chiao Chang 24, 25 Clive Gray 26, 27 Yusuke Nakamura 28 William D. Lees 29 Purvesh Khatri 6 Houda Alachkar 1 Cathrine Scheepers 30, 31 Corey T. Watson 3 Gunilla B. Karlsson Hedestam 8 Serghei Mangul 1, * 
Abstract : Immunogenomics studies have been largely limited to individuals of European ancestry, restricting the ability to identify variation in human adaptive immune responses across populations. Inclusion of a greater diversity of individuals in immunogenomics studies will substantially enhance our understanding of human immunology.
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Submitted on : Wednesday, May 26, 2021 - 11:42:42 AM
Last modification on : Thursday, April 7, 2022 - 10:10:54 AM

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Kerui Peng, Yana Safonova, Mikhail Shugay, Alice B. Popejoy, Oscar L. Rodriguez, et al.. Diversity in immunogenomics: the value and the challenge. Nature Methods, Nature Publishing Group, 2021, ⟨10.1038/s41592-021-01169-5⟩. ⟨pasteur-03236474⟩

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