Skip to Main content Skip to Navigation
Journal articles

Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus

Abstract : We report two outbreaks of Lassa fever that occurred in Benin in 2014 and 2016 with 20 confirmed cases and 50% (10/20) mortality. Benin was not previously considered to be an endemic country for Lassa fever, resulting in a delay to diagnose the disease and its human transmission. Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage. Endemic circulation of Lassa virus in a new territory and the genetic diversity thus confirm that this virus represents a growing threat for West African people. Given the divergence of the Benin strain from the prototypic Josiah Sierra Leone strain frequently used to generate vaccine candidates, the efficacy of vaccine candidates should also be demonstrated with this strain.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03236129
Contributor : Sylvain Baize <>
Submitted on : Wednesday, May 26, 2021 - 10:31:12 AM
Last modification on : Tuesday, June 15, 2021 - 3:07:15 AM

File

EMI_2020.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Anges Yadouleton, Caroline Picard, Toni Rieger, Frederic Loko, Daniel Cadar, et al.. Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus. Emerging microbes & infections, Earliest : Springer-Nature ; Latest : Taylor & Francis, 2020, 9 (1), pp.1761 - 1770. ⟨10.1080/22221751.2020.1796528⟩. ⟨pasteur-03236129⟩

Share

Metrics

Record views

24

Files downloads

46