Skip to Main content Skip to Navigation
Journal articles

Differential Relation between Neuronal and Behavioral Discrimination during Hippocampal Memory Encoding

Abstract : How are distinct memories formed and used for behavior? To relate neuronal and behavioral discrimination during memory formation, we use in vivo 2-photon Ca 2+ imaging and whole-cell recordings from hippocampal subregions in head-fixed mice performing a spatial virtual-reality task. We find that both subthreshold activity as well as population codes of dentate gyrus neurons robustly discriminate across different spatial environments, while neuronal remapping in CA1 depends on the degree of difference between visual cues. Moreover, neuronal discrimination in CA1, but not in the dentate gyrus, reflects behavioral performance. Our results suggest that CA1 weights the decorrelated information from the dentate gyrus according to its relevance, thereby producing a map of memory representations that can be used by downstream circuits to guide learning and behavior.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03235036
Contributor : Christoph Schmidt-Hieber <>
Submitted on : Tuesday, May 25, 2021 - 3:59:41 PM
Last modification on : Thursday, May 27, 2021 - 3:34:15 AM

File

1-s2.0-S089662732030756X-main....
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Manuela Allegra, Lorenzo Posani, Ruy Gómez-Ocádiz, Christoph Schmidt-Hieber. Differential Relation between Neuronal and Behavioral Discrimination during Hippocampal Memory Encoding. Neuron, Elsevier, 2020, 108 (6), pp.1103-1112.e6. ⟨10.1016/j.neuron.2020.09.032⟩. ⟨pasteur-03235036⟩

Share

Metrics

Record views

19

Files downloads

29